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Evidence-Based Complementary and Alternative Medicine
Volume 7 (2010), Issue 3, Pages 317-322
Original Article

Lipid Lowering Activity of Anthocephalus indicus Root in Hyperlipidemic Rats

1Department of Biochemistry, Era's Lucknow Medical College & Hospital, Lucknow-226003, India
2Division of Biochemistry, Central Drug Research Institute, Lucknow-226001, India
3Department of Biochemistry, King George's Medical University, Lucknow-226003, India

Received 10 July 2007; Accepted 17 December 2007

Copyright © 2010 Vishnu Kumar et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


The lipid lowering activity of Anthocephalus indicus (family Rubiaceae; Hindi name Kadamba) root extract has been studied in triton WR-1339 induced hyperlipidemia in rats. In this model, feeding with root extract (500 mg kg−1 b.w.) lowered plasma lipids and reactivated post-heparin lipolytic activity in hyperlipidemic rats. Furthermore, the root extract (50–500 μM) inhibited the generation of superoxide anions and hydroxyl radicals, in both enzymic and non-enzymic systems, in vitro. The results of the present study demonstrated both lipid lowering and antioxidant activities in root extract of A. indicus, which could help prevention of hyperlipidemia and related diseases.