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Evidence-Based Complementary and Alternative Medicine
Volume 2011, Article ID 103425, 6 pages
Research Article

Novel 5,6-Dihydropyrrolo[2,1-a]isoquinolines as Scaffolds for Synthesis of Lamellarin Analogues

1College of Environment and Chemical Engineering, Dalian University, Dalian 116622, China
2Liaoning Key Laboratory of Bio-Organic Chemistry, Dalian University, Dalian 116622, China
3College of Agronomy, Northwest A&F University, Yangling 712100, China

Received 31 December 2010; Accepted 3 June 2011

Copyright © 2011 Shao Han Liao et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


As core skeletons of lamellarins: 5,6-Dihydropyrrolo[2,1-a]isoquinolines are one of the important alkaloids that exhibit significant biological activities, in this study, an efficient synthetic route was described for two novel compounds, 5,6-dihydropyrrolo[2,1-a]isoquinolines I and II. Compound I was synthesized from isovanillin with 28.3% overall yield by a six-step reaction while II from 2-(3,4-dimethoxyphenyl) ethanamine was with 61.6% overall yield by a three-step reaction. And the structures of these two compounds were confirmed by means of IR spectrum, 1H NMR, 13C NMR, MS, HRMS, and melting point measurements.