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Evidence-Based Complementary and Alternative Medicine
Volume 2011, Article ID 109809, 8 pages
Original Article

Paeoniae alba Radix Promotes Peripheral Nerve Regeneration

1Graduate Institute of Chinese Medical Science, China Medical University, Taiwan
2Division of Neurosurgery, China Medical University Hospital, Taiwan
3Department of Health and Nutrition Biotechnology, Asia University, Taiwan
4Department Biomedical Imaging and Radiological Science, China Medical University, Taichung, Taiwan

Received 25 March 2009; Accepted 21 July 2009

Copyright © 2011 Kun-Shan Huang et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


The present study provides in vitro and in vivo evaluation of Paeoniae alba Radix (PR) on peripheral nerve regeneration. In the in vitro study, we found the PR caused a marked enhancement of the nerve growth factor-mediated neurite outgrowth from PC12 cells as well as their expression of growth associated protein 43 and synapsin I. In the in vivo study, silicone rubber chambers filled with the PR water extract were used to bridge a 10-mm sciatic nerve defect in rats. At the conclusion of 8 weeks, regenerated nerves in the PR groups, especially at 1.25 mg ml−1 had a higher rate of successful regeneration across the wide gap, relatively larger mean values of total nerve area, myelinated axon count and blood vessel number, and a significantly larger nerve conductive velocity compared to the control group ( ). These results suggest that the PR extract can be a potential nerve growth-promoting factor, being salutary in aiding the growth of injured peripheral nerve.