Antinociceptive Activity of Trichilia catigua Hydroalcoholic Extract: New Evidence on Its Dopaminergic Effects
Effect therapeutic treatment with T. catigua extract (200 mg kg−1, p.o.), morphine (4 mg kg−1, s.c.) and indomethacin (5 mg kg−1, i.p.) on the mechanical hypersensitivity induced by carrageenan (300 g/50 l/paw, i.pl.) in mice. (a) Time-course of the anti-hypernociceptive effect; (b) AUC of the anti-hypernociceptive effect. Results represent the mean SEM; n = 6–8 animals per group. * significantly different from PBS PBS-treated mice; # significantly different from PBS carrageenan-treated mice; a significantly different from morphine and indomethacin-treated mice (ANOVA followed by Newmann-Keuls post-hoc test).