Evidence-Based Complementary and Alternative Medicine / 2011 / Article / Tab 1

Original Article

Antinociceptive Activity of Trichilia catigua Hydroalcoholic Extract: New Evidence on Its Dopaminergic Effects

Table 1

Influence of several drugs on T. catigua hydroalcoholic extract antinociception effect expressed as MPE (%).

Treatment (dose)Antagonist (dose)Site/mechanism of actionMPE (%)

Morphine (5 mg kg−1, s.c.)PBS100
Naloxone (2.5 mg kg−1, i.p.)Non-specific opioid receptor antagonist0
T. catigua (200 mg kg−1, p.o.)PBS39     10
Prazosin (1 mg kg−1, i.p.) 1-adrenergic receptor antagonist,38     8
SR141716A (10 mg kg−1, i.p.)Cannabinoid receptor antagonist45     7
SCH23390 (15  g kg−1, i.p.)D1 receptor antagonist0
Sulpiride (50 mg kg−1, i.p.)D2 receptor antagonist48     12
Bicuculline (1 mg kg−1, i.p.)GABAA receptor antagonist22     10
Naloxone (2.5 mg kg−1, i.p.)Non-specific opioid receptor antagonist20     13
PCPA (100 mg kg−1, i.p.)Serotonin synthesis inhibitor48     8

Each group represents the mean     SEM of 10 animals.