Original Article
Antinociceptive Activity of Trichilia catigua Hydroalcoholic Extract: New Evidence on Its Dopaminergic Effects
Table 1
Influence of several drugs on T. catigua hydroalcoholic extract antinociception effect expressed as MPE (%).
| Treatment (dose) | Antagonist (dose) | Site/mechanism of action | MPE (%) |
| Morphine (5 mg kg−1, s.c.) | PBS | — | 100 | | Naloxone (2.5 mg kg−1, i.p.) | Non-specific opioid receptor antagonist | 0 | T. catigua (200 mg kg−1, p.o.) | PBS | — | 39 10 | | Prazosin (1 mg kg−1, i.p.) | 1-adrenergic receptor antagonist, | 38 8 | | SR141716A (10 mg kg−1, i.p.) | Cannabinoid receptor antagonist | 45 7 | | SCH23390 (15 g kg−1, i.p.) | D1 receptor antagonist | 0 | | Sulpiride (50 mg kg−1, i.p.) | D2 receptor antagonist | 48 12 | | Bicuculline (1 mg kg−1, i.p.) | GABAA receptor antagonist | 22 10 | | Naloxone (2.5 mg kg−1, i.p.) | Non-specific opioid receptor antagonist | 20 13 | | PCPA (100 mg kg−1, i.p.) | Serotonin synthesis inhibitor | 48 8 |
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Each group represents the mean SEM of 10 animals.
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