Efficacy and Safety Assessment of T. Angelica Herbal Tonic, a Phytomedicinal Product Popularly Used in Nigeria

Table 2

Effects of TAHT on gastrointestinal motility in mice.

Agents	Dose (mg kg^−1)	Percentage of intestinal transit
Carbachol	40	73.03 ± 5.72*
Normal saline	20 mL kg^−1	56.02 ± 6.88
TAHT	200 mg kg^−1	65.90 ± 4.02
TAHT	400 mg kg^−1	70.93 ± 2.71*

Albino mice were placed randomly into four groups and were starved for 24 h prior to the experiment. The first two groups received 200 and 400 mg kg⁻¹ of the TAHT, respectively, while the 3rd and 4th groups received carbachol (40 mg kg⁻¹) and normal saline (10 mL kg⁻¹). After 5 min of drug administration, 0.5 mL of 5% charcoal dispersion in tragacanth mucilage was administered orally to each animal. The animals were sacrificed 30 min later and the percentage of distance traveled by the charcoal plug in the small intestine (from the pylorus to the caecum) were determined and compared with the negative control.
*Significant P < .05 versus control.