Anti-Hyperglycemic Properties of Crude Extract and Triterpenes from Poria cocos
Figure 2
Single-dose effects of crude extract, fractions, sub-fractions, and triterpenes of P. cocos on the level of postprandial blood glucose in db/db mice. (a) Diabetic db/db mice were tube-fed with water (Ctr), metformin (Met: 60 mg/kg BW), and crude extract (CE: 10, 50 or 100 mg/kg BW). Blood glucose levels were measured before (0 h) and after (1 to 4 h) tube feeding. (b) The same procedure as (a) except that water (Ctr), metformin (Met: 60 mg/kg BW), water fraction (Water: 50 mg/kg BW), ethyl acetate fraction (EA: 50 mg/kg BW), and chloroform fraction (Chl, 50 mg/kg BW) were administered. (c) The same procedure as (a) except that water (Ctr), metformin (Met: 60 mg/kg BW), and 6 chloroform sub-fractions (Chl-1 to Chl-6: 50 mg/kg BW) were administered. (d), The same procedure as (a) except that DMSO/water (Ctr), metformin (Met: 60 mg/kg), dehydrotumulosic acid (DHTuA: 1, 5, and 10 mg/kg BW), pachymic acid (PA: 1, 5, and 10 mg/kg BW), and dehydrotrametenolic acid (DHTA: 1, 5, and 10 mg/kg BW) were administered. All the above data are expressed as P; () less than .05 is considered to be statistically significant. The mouse number () is indicated in parenthesis.
