[Retracted] Protective Effects of Rosa damascena and Its Active Constituent on Aβ(25–35)-Induced Neuritic Atrophy
Figure 1
Protective effects of rose extract on Aβ(25–35)-induced dendritic atrophy and cell death. Cortical neurons were cultured for three days and were then treated with (Veh) or without 10 μM Aβ(25–35) (Cont). Cells were simultaneously treated by the chloroform extract of Rosa damascena (0.5, 5 μg/mL, RE) or vehicle (0.1% DMSO, Veh). (a) Five days after treatment, the cells were fixed and immunostained for MAP2a&2b. The lengths of MAP2a&2b-positive neurites were measured. Values are means ± SE of data from four areas. (b) After cultivation for three days, the cortical neurons were treated with (Veh) or without (Cont) 10 μM Aβ(25–35). The cells were simultaneously treated with the chloroform extract of Rosa damascena (5 μg/mL, RE), (Gly14)-Humanin (100 nM, HN) or vehicle (Veh). Four days after the treatment, cell viability was measured. Values are means ± SE of data from sex areas. *P < 0.05 versus Aβ(25–35)/Veh (one-way ANOVA followed by Dunnett's post hoc test). Typical photographs were shown.
