S-Petasin, the Main Sesquiterpene of Petasites formosanus, Inhibits Phosphodiesterase Activity and Suppresses Ovalbumin-Induced Airway Hyperresponsiveness
Effect of S-petasin (10–30 mol/kg, s.c.) on P enh (a), inflammatory cells (b), and cytokines (c) in sensitized mice which received aerosolized MCh (6.25–50 mg/mL) 2 days after secondary allergen challenge. , , and , compared to the vehicle (control). The number of mice in each group was 10. Total, total cells; Mac, macrophages; Lym, lymphocytes; Neu, neutrophils; Eos, eosinophils; IL, interleukin; TNF-, tumor necrosis factor-; TNF-, tumor necrosis factor-.