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Evidence-Based Complementary and Alternative Medicine
Volume 2011, Article ID 134378, 10 pages
http://dx.doi.org/10.1093/ecam/nep015
Original Article

Wound Healing Activity of Topical Application Forms Based on Ayurveda

1Interdisciplinary School of Health Sciences, University of Pune, Ganeshkhind, Pune 411007, India
2The Himalaya Drug Company, Makali, Bangalore 562 123, India
3Manipal Education, 14 Airport Road, Manipal Towers, Bangalore 560 008, India

Received 25 July 2008; Accepted 16 January 2009

Copyright © 2011 Hema Sharma Datta et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

The traditional Indian medicine—Ayurveda, describes various herbs, fats, oils and minerals with anti-aging as well as wound healing properties. With aging, numerous changes occur in skin, including decrease in tissue cell regeneration, decrease in collagen content, loss of skin elasticity and mechanical strength. We prepared five topical anti-aging formulations using cow ghee, flax seed oil, Phyllanthus emblica fruits, Shorea robusta resin, Yashada bhasma as study materials. For preliminary efficacy evaluation of the anti-aging activity we chose excision and incision wound healing animal models and studied the parameters including wound contraction, collagen content and skin breaking strength which in turn is indicative of the tissue cell regeneration capacity, collagenation capacity and mechanical strength of skin. The group treated with the formulations containing Yashada bhasma along with Shorea robusta resin and flax seed oil showed significantly better wound contraction (P < .01), higher collagen content (P < .05) and better skin breaking strength (P < .01) as compared to control group; thus proposing them to be effective prospective anti-aging formulations.