Cytotoxic Activity of Crude Extracts as well as of Pure Components from Jatropha Species, Plants Used Extensively in African Traditional Medicine

Table 2

Cytotoxic activity of compounds isolated from Jatropha curcas root extracts. The EC₅₀ values are given here; the SD’s of the respective values are less than 15%.

Compounds	EC50 (μg/mL) for L5178y cells
Curcusone C	0.08
Curcusone D	0.16
2-Hydroxyisojatrogrossidion	0.20
Curcusone A	0.21
2-epi-hydroxyisojatrogrossidion	0.24
Curcusone B	0.27
4Z-jatrogrossidentadion	0.60
15-epi-4E-jatrogrossidentadion	0.85
4E-jatrogrossidentadion	2.10
Acetoxyjatropholone	2.50
Multidione	5.50
Jatropholone	7.50
Curcusone E	>10
Spirocurcasone	>10