Myricetin Ameliorates Defective Post-Receptor Insulin Signaling via β-Endorphin Signaling in the Skeletal Muscles of Fructose-Fed Rats

Table 2

Quantification of the protein expression of specific insulin receptor-related signaling mediators in soleus muscles of fructose-fed rats receiving 14-day treatment with myricetin or myricetin plus MOR antagonist.

Relative units	Fructose-fed rats
	Vehicle	Myricetin	Myricetin + β-FNA
IR	1.00 ± 0.07	1.04 ± 0.06	0.99 ± 0.05
IRS-1	1.01 ± 0.06	1.18 ± 0.05^a	1.02 ± 0.08
p85	1.01 ± 0.05	1.21 ± 0.07^a	1.08 ± 0.04
Akt	1.00 ± 0.08	1.15 ± 0.06^a	0.96 ± 0.09
AS160	1.01 ± 0.07	1.17 ± 0.04^a	1.03 ± 0.06

Fructose-fed rats received i.v. injection of myricetin (1 mg kg^-1), thrice daily for 14 days. β-FNA (10 𝜇g kg^-1) was i.v. injected 30 min prior to administration of myricetin. The vehicle used to dissolve the tested drugs was given at the same volume. Values (mean ± SEM) were obtained from 5 rats. ^aP < .05 represents the level of significance compared to the values of the vehicle-treated group.