Table of Contents Author Guidelines Submit a Manuscript
Evidence-Based Complementary and Alternative Medicine
Volume 2011, Article ID 160682, 9 pages
http://dx.doi.org/10.1093/ecam/nep214
Original Article

Analyzing Cytotoxic and Apoptogenic Properties of Scutellaria litwinowii Root Extract on Cancer Cell Lines

1Department of Pharmacology, School of Medicine, Mashhad University of Medical Sciences, Iran
2Pharmacological Research Centre of Medicinal Plants, School of Medicine, Mashhad University of Medical Sciences, Iran
3Department of Pharmacognosy, School of Pharmacy, Mashhad University of Medical Sciences, Iran
4Medical Toxicology Research Center, Mashhad University of Medical Sciences, Mashhad, Iran

Received 15 July 2009; Accepted 24 November 2009

Copyright © 2011 Zahra Tayarani-Najaran et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Citations to this Article [23 citations]

The following is the list of published articles that have cited the current article.

  • Prabha Balaram, and Faizah Harun, “Evidence-based Anticancer Materia Medica for Brain Tumors,” Materia Medica for Various Cancers, vol. 2, pp. 285–313, 2011. View at Publisher · View at Google Scholar
  • Jinxiu Xu, Xinyan Wang, Mu Yang, and Hong Zhou, “Chloroform extract of Tibetan herbal medicine Dracocephalum tanguticum Maxim. inhibits proliferation of T98G glioblastomas cells by modulating Caspase-3 cleavage and expression of Bax and p21,” Journal of Medicinal Plant Research, vol. 5, no. 25, pp. 6024–6031, 2011. View at Publisher · View at Google Scholar
  • Joabe Gomes de Melo, Ariane Gaspar Santos, Elba Lúcia Cavalcanti de Amorim, Silene Carneiro do Nascimento, and Ulysses Paulino de Albuquerque, “Medicinal Plants Used as Antitumor Agents in Brazil: An Ethnobotanical Approach,” Evidence-Based Complementary and Alternative Medicine, vol. 2011, pp. 1–14, 2011. View at Publisher · View at Google Scholar
  • Raktim Biswas, Sushil Kumar Mandal, Suman Dutta, Soumya Sundar Bhattacharyya, Naoual Boujedaini, and Anisur Rahman Khuda-Bukhsh, “Thujone-Rich Fraction of Thuja occidentalis Demonstrates Major Anti-Cancer Potentials: Evidences from In Vitro Studies on A375 Cells,” Evidence-Based Complementary and Alternative Medicine, vol. 2011, pp. 1–16, 2011. View at Publisher · View at Google Scholar
  • Daisuke Sato, Seiji Kondo, Kazunaga Yazawa, Yoshiki Mukudai, Chunnan Li, Takaaki Kamatani, Hideyuki Katsuta, Yasuto Yoshihama, Tatsuo Shirota, and Satoru Shintani, “The potential anticancer activity of extracts derived from the roots of Scutellaria baicalensis on human oral squamous cell carcinoma cells,” Molecular and Clinical Oncology, vol. 1, no. 1, pp. 105–111, 2012. View at Publisher · View at Google Scholar
  • Zahra Tayarani-Najarani, Javad Asili, Heydar Parsaee, Seyed Hadi Mousavi, Naser Vadati Mashhadian, Alireza Mirzaee, and Seyed Ahmad Emami, “Wogonin and neobaicalein from Scutellaria litwinowii roots are apoptotic for HeLa cells,” Revista Brasileira De Farmacognosia-Brazilian Journal Of Pharmacognosy, vol. 22, no. 2, pp. 268–276, 2012. View at Publisher · View at Google Scholar
  • Zahra Tayarani-Najaran, Seyed Hadi Mousavi, Nasser Vahdati-Mashhadian, Seyed Ahmad Emami, and Heydar Parsaee, “ Scutellaria litwinowii Induces Apoptosis Through Both Extrinsic and Intrinsic Apoptotic Pathways in Human Promyelocytic Leukemia Cells ,” Nutrition and Cancer, vol. 64, no. 1, pp. 80–88, 2012. View at Publisher · View at Google Scholar
  • Maryam Afsharzadeh, Zahra Tayarani-Najaran, Aryo Zare, and Seyed Hadi Mousavi, “Protective Effect of Scutellaria litwinowii Extract on Serum/Glucose-Deprived Cultured PC12 Cells and Determining the Role of Reactive Oxygen Species,” Journal of Toxicology, vol. 2012, pp. 1–6, 2012. View at Publisher · View at Google Scholar
  • Begum Yurdakok, and Emine Baydan, “Cytotoxic effects of Eryngium kotschyi and Eryngium maritimum on Hep2, HepG2, Vero and U138 MG cell lines,” Pharmaceutical Biology, vol. 51, no. 12, pp. 1579–1585, 2013. View at Publisher · View at Google Scholar
  • Chi-Chiu Lee, Hernyi Justin Hsieh, Cheng-Hong Hsieh, and Deng-Fwu Hwang, “Spine venom of crown-of-thorns starfish (Acanthaster planci) induces antiproliferation and apoptosis of human melanoma cells (A375.S2),” Toxicon, 2014. View at Publisher · View at Google Scholar
  • Yi-Hu Zheng, Li-Hui Yin, Tan Hooi Min Grahn, Ai-Fang Ye, Yan-Rong Zhao, and Qi-Yu Zhang, “Anticancer Effects of Baicalein on Hepatocellular Carcinoma Cells,” Phytotherapy Research, vol. 28, no. 9, pp. 1342–1348, 2014. View at Publisher · View at Google Scholar
  • Zahra Tayarani-Najaran, Atefeh Amiri, Gholamreza Karimi, Seyed Ahmad Emami, Javad Asili, and Seyed Hadi Mousavi, “ Comparative Studies of Cytotoxic and Apoptotic Properties of Different Extracts and the Essential Oil of Lavandula angustifolia on Malignant and Normal Cells ,” Nutrition and Cancer, pp. 140226085535001, 2014. View at Publisher · View at Google Scholar
  • Motahareh Boozari, Ameneh Mohammadi, Javad Asili, Seyed Ahmad Emami, and Zahra Tayarani-Najaran, “Growth inhibition and apoptosis induction by Scutellaria pinnatifida A. Ham. on HL-60 and K562 leukemic cell lines,” Environmental Toxicology and Pharmacology, 2014. View at Publisher · View at Google Scholar
  • Ameneh Eshaghi, Javad Asili, Hamideh Parhiz, Seyed Ahmad Emami, Fatemeh Mosaffa, Sousan Shojaee, and Javad Behravan, “In vitro protective effects of Scutellaria litwinowii root extract against H2O2-induced DNA damage and cytotoxicity,” Journal of Complementary and Integrative Medicine, vol. 11, no. 2, pp. 121–127, 2014. View at Publisher · View at Google Scholar
  • Hong-Tai Chang, Chiang-Ting Chou, Daih-Huang Kuo, Pochuen Shieh, Chung-Ren Jan, and Wei-Zhe Liang, “ The Mechanism of Ca 2+ Movement in the Involvement of Baicalein-Induced Cytotoxicity in ZR-75-1 Human Breast Cancer Cells ,” Journal of Natural Products, pp. 150708104358005, 2015. View at Publisher · View at Google Scholar
  • Rhun Yian Koh, Khuen Yen Ng, Yi Chi Sim, Hwee Jin Toh, Liang Kuan Liam, Rachael Sze Lynn Ong, Mei Yeng Yew, Yee Lian Tiong, Anna Pick Kiong Ling, and Soi Moi Chye, “Cytotoxic and apoptogenic effects of Strobilanthes crispa Blume extracts on nasopharyngeal cancer cells,” Molecular Medicine Reports, vol. 12, no. 4, pp. 6293–6299, 2015. View at Publisher · View at Google Scholar
  • Shan Hu, Yu Chen, Zhi-Fu Wang, Qi-Liang Mao-Ying, Wen-Li Mi, Jian-Wei Jiang, Gen-Cheng Wu, and Yan-Qing Wang, “The Analgesic and Antineuroinflammatory Effect of Baicalein in Cancer-Induced Bone Pain,” Evidence-Based Complementary and Alternative Medicine, vol. 2015, pp. 1–8, 2015. View at Publisher · View at Google Scholar
  • Mohamad Hassanzadeh Khayyat, Zahra Tayarani-Najaran, Reza Rahimzadeh Oskooie, Javad Asili, Arezoo Rajabian, and Seyed Ahmad Emami, “Phytochemical evaluation and antioxidant activity of essential oil, and aqueous and organic extracts of Artemisia dracunculus,” Jundishapur Journal of Natural Pharmaceutical Products, vol. 12, no. 1, 2017. View at Publisher · View at Google Scholar
  • Zahra Tayarani-Najaran, Arehzoo Zaker, Javad Asili, Parvaneh Abrishamchi, and Seyed Hadi Mousavi, “Cytotoxic and apoptotic effects of root extract and tanshinones isolated from Perovskia abrotanoides kar,” Iranian Journal of Basic Medical Sciences, vol. 20, no. 12, pp. 1377–1384, 2017. View at Publisher · View at Google Scholar
  • Amir Sasan Mozaffari Nejad, Leila Mahmoodnia, Mahmoud Bahmani, Naseer Ali Shah, Sayed Afzal Shah, and Mahmoud Rafieian-Kopaei, “Survey on ethnobotanical uses of anti-cancer herbs in southern region of Ilam, west Iran,” Journal of Biological Research (Italy), vol. 90, no. 1, 2017. View at Publisher · View at Google Scholar
  • Srinivasa Reddy Bonam, Yuan Seng Wu, Lakshmi Tunki, Ranjithkumar Chellian, Mahabalarao Sampath Kumar Halmuthur, Sylviane Muller, and Vijayapandi Pandy, “What Has Come out from Phytomedicines and Herbal Edibles for the Treatment of Cancer?,” ChemMedChem, 2018. View at Publisher · View at Google Scholar
  • Samira EghbaliFeriz, Akram Taleghani, and Zahra Tayarani-Najaran, “Central nervous system diseases and Scutellaria : a review of current mechanism studies,” Biomedicine & Pharmacotherapy, vol. 102, pp. 185–195, 2018. View at Publisher · View at Google Scholar
  • E Alinejad-Mofrad, B Malaekeh-Nikouei, L Gholami, Sh Mousavi, Hr Sadeghnia, M Mohajeri, M Darroudi, and Rk Oskuee, “ Evaluation and comparison of cytotoxicity, genotoxicity, and apoptotic effects of poly- l -lysine/plasmid DNA micro- and nanoparticles ,” Human & Experimental Toxicology, pp. 096032711984692, 2019. View at Publisher · View at Google Scholar