Cytotoxic Activities of Physalis minima L. Chloroform Extract on Human Lung Adenocarcinoma NCI-H23 Cell Lines by Induction of Apoptosis

Figure 7

An Overview of apoptotic effects elicited by P. minima chloroform extract on NCI-H23 cells. The apoptotic mechanism was mediated by the activation of p53 (inducer and regulator), caspase-3 (executioner) and c-myc (enhancer dotted lines) which were reputed as main molecular regulators in both extrinsic and intrinsic pathway. This was subsequently resulting in biochemical and morphological alterations, including DNA fragmentation; phosphatidylserine (PS) externalization, chromatin migration, membrane blebbing and apoptotic bodies.