Comparison of Adjunctive Naoxintong versus Clopidogrel in Volunteers with the CYP2C19^*2 Gene Mutation Accompanied with Qi Deficiency and Blood Stasis Constitution

Table 2

Comparison of platelet aggregation with 5-μmol/L ADP at baseline and after therapy.

Baseline

After single clopidogrel administration

7d after washing

5d after single BNJ administration

7d after BNJ combined- clopidogrel

time

0 h

4 h

𝑃 value

24 h

𝑃 value

3 d

𝑃 value

7 d

𝑃 value

14 d

𝑃 value

19 d

𝑃 value

26 d

𝑃 value

Aggmax, %

CYP2C19*1/*1 (𝑛=6)

60.6±5.6

23.3±4.3

<.001

22.1±2.3

<.001

24.4±4.2

<.001

22.3±2.8

<.001

70.4±4.8

.012

23.3±2.7

<.001

22.6±1.2

<.001

<.001*

<.001*

CYP2C19*1/*2 (𝑛=6)

66.9±13.7

34.3±4.5

.005

33.6±3.2

.004

34.7±3.5

.004

33.0±3.3

.005

69.7±4.1

.616

24.1±5.2

.001

24.7±5.0

.001

.001*

.001*

CYP2C19*2/*2 (𝑛=6)

62.9±4.4

53.0±3.0

.001

53.3±2.1

.004

55.1±2.6

.016

54.1±3.5

.015

67.3±3.8

.014

25.8±3.8

<.001

22.7±2.2

<.001

<.001*

<.001*

Agglate, %

CYP2C19*1/*1 (𝑛=6)

59.3±5.8

22.2±3.9

<.001

21.2±2.4

<.001

23.1±4.2

<.001

21.2±2.3

<.001

69.5±4.8

.012

22.1±2.5

<.001

21.4±1.2

<.001

<.001*

<.001*

CYP2C19*1/*2 (𝑛=6)

64.3±13.4

32.4±3.2

.006

33.5±3.5

.004

33.5±3.6

.005

31.9±5.3

.006

68.1±4.4

.502

22.9±5.1

.002

23.2±5.2

.002

.000*

.000*

CYP2C19*2/*2 (𝑛=6)

58.2±6.6

55.0 ± 5.2

.003

52.25±2.24

.007

53.7±2.2

.016

52.9±3.5

.021

66.0±4.1

.021

24.6±3.4

<.001

21.5±2.1

<.001

<.001*

<.001*

Note: values are presented as mean ± SD. The 𝑃 values are for comparison to baseline. *The 𝑃 values are for comparison to washing. ADP: adenosine diphosphate; Agg_max: maximal platelet aggregation; Agg_late: late platelet aggregation at 5 min.