Protective Mechanism of KIOM-4 in Streptozotocin-Induced Pancreatic β-Cells Damage Is Involved in the Inhibition of Endoplasmic Reticulum Stress

Figure 2

The effects of KIOM-4 on STZ-induced mitochondrial Ca²⁺ overloading and ER staining. Cells were treated with fluorescent probe Rhod-2 AM. The mitochondrial Ca²⁺ levels were measured by (a) flow cytometry as described in Section 2. FI indicates the fluorescence intensity of Rhod-2 AM. ((b) and (c)) Cells were treated with ER Tracker Blue-White DPX for ER staining as describe in Section 2.

(a)

(b)

(c)