Table of Contents Author Guidelines Submit a Manuscript
Evidence-Based Complementary and Alternative Medicine
Volume 2011, Article ID 231938, 10 pages
http://dx.doi.org/10.1155/2011/231938
Research Article

Protective Mechanism of KIOM-4 in Streptozotocin-Induced Pancreatic β-Cells Damage Is Involved in the Inhibition of Endoplasmic Reticulum Stress

1School of Medicine, Jeju National University, Jeju-si 690-756, Republic of Korea
2Diabetic Complication Research Center, Division of Traditional Korean Medicine Integrated Research, Korea Institute of Oriental Medicine, Daejeon 305-811, Republic of Korea

Received 19 June 2010; Accepted 27 August 2010

Copyright © 2011 Rui Zhang et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. J. Saito, Y. Sakai, and H. Nagase, “In vitro anti-mutagenic effect of magnolol against direct and indirect mutagens,” Mutation Research, vol. 609, no. 1, pp. 68–73, 2006. View at Publisher · View at Google Scholar · View at Scopus
  2. E. J. Park, S. Y. Kim, Y. Z. Zhao, and D. H. Sohn, “Honokiol reduces oxidative stress, c-jun-NH2-terminal kinase phosphorylation and protects against glycochenodeoxycholic acid-induced apoptosis in primary cultured rat hepatocytes,” Planta Medica, vol. 72, no. 7, pp. 661–664, 2006. View at Publisher · View at Google Scholar · View at Scopus
  3. A. H. Cao, L. T. Vo, and R. G. King, “Honokiol protects against carbon tetrachloride induced liver damage in the rat,” Phytotherapy Research, vol. 19, no. 11, pp. 932–937, 2005. View at Publisher · View at Google Scholar · View at Scopus
  4. Y. R. Lin, H. H. Chen, C. H. Ko, and M. H. Chan, “Neuroprotective activity of honokiol and magnolol in cerebellar granule cell damage,” European Journal of Pharmacology, vol. 537, no. 1-3, pp. 64–69, 2006. View at Publisher · View at Google Scholar · View at Scopus
  5. J. Lee, E. Jung, J. Park et al., “Anti-inflammatory effects of magnolol and honokiol are mediated through inhibition of the downstream pathway of MEKK-1 in NF-κB activation signaling,” Planta Medica, vol. 71, no. 4, pp. 338–343, 2005. View at Publisher · View at Google Scholar · View at Scopus
  6. K. Y. Ho, C. C. Tsai, C. P. Chen, J. S. Huang, and C. C. Lin, “Antimicrobial activity of honokiol and magnolol isolated from Magnolia officinalis,” Phytotherapy Research, vol. 15, no. 2, pp. 139–141, 2001. View at Publisher · View at Google Scholar · View at Scopus
  7. S. J. Lee, Y. H. Cho, K. Park et al., “Inhibitory effects of the aqueous extract of Magnolia officinalis on the responses of human urinary bladder cancer 5637 cells in vitro and mouse urinary bladder tumors induced by N-butyl-N-(4-hydroxybutyl) nitrosamine in vitro,” Phytotherapy Research, vol. 23, no. 1, pp. 20–27, 2009. View at Publisher · View at Google Scholar · View at Scopus
  8. W. Y. Tam, P. Chook, M. Qiao et al., “The efficacy and tolerability of adjunctive alternative herbal medicine (Salvia miltiorrhiza and Pueraria lobata) on vascular function and structure in coronary patients,” Journal of Alternative and Complementary Medicine, vol. 15, no. 4, pp. 415–421, 2009. View at Publisher · View at Google Scholar · View at Scopus
  9. M. Miyazawa, K. Sakano, S. I. Nakamura, and H. Kosaka, “Antimutagenic activity of isoflavone from Pueraria lobata,” Journal of Agricultural and Food Chemistry, vol. 49, no. 1, pp. 336–341, 2001. View at Publisher · View at Google Scholar · View at Scopus
  10. K. T. Lee, I. C. Sohn, D. H. Kim, J. W. Choi, S. H. Kwon, and H. J. Park, “Hypoglycemic and hypolipidemic effects of tectorigenin and kaikasaponin III in the streptozotocin-lnduced diabetic rat and their antioxidant activity in vitro,” Archives of Pharmacal Research, vol. 23, no. 5, pp. 461–466, 2000. View at Google Scholar · View at Scopus
  11. K. T. Lee, I. C. Sohn, Y. K. Kim et al., “Tectorigenin, an isoflavone of Pueraria thunbergiana BENTH., induces differentiation and apoptosis in human promyelocytic leukemia HL-60 cells,” Biological and Pharmaceutical Bulletin, vol. 24, no. 10, pp. 1117–1121, 2001. View at Publisher · View at Google Scholar · View at Scopus
  12. H. Liao, L. K. Banbury, and D. N. Leach, “Elucidation of Danzhixiaoyao Wan and its constituent herbs on antioxidant activity and inhibition of nitric oxide production,” Evidence-Based Complementary and Alternative Medicine, vol. 4, no. 4, pp. 425–430, 2007. View at Publisher · View at Google Scholar · View at Scopus
  13. Z. Y. Wang and D. W. Nixon, “Licorice and cancer,” Nutrition and Cancer, vol. 39, no. 1, pp. 1–11, 2001. View at Google Scholar · View at Scopus
  14. D. G. Popovich, S. Y. Yeo, and W. Zhang, “Ginseng (Panax quinquefolius) and Licorice (Glycyrrhiza uralensis) root extract combinations increase hepatocarcinoma cell (Hep-G2) viability,” Evidence-Based Complementary and Alternative Medicine. In press.
  15. M. J. Ahn, Y. K. Chul, S. L. Ji et al., “Inhibition of HIV-1 integrase by galloyl glucoses from Terminalia chebula and flavonol glycoside gallates from Euphorbia pekinensis,” Planta Medica, vol. 68, no. 5, pp. 457–459, 2002. View at Publisher · View at Google Scholar · View at Scopus
  16. L. Y. Kong, Y. Li, X. L. Wu, and Z. D. Min, “Cytotoxic diterpenoids from Euphorbia pekinensis,” Planta Medica, vol. 68, no. 3, pp. 249–252, 2002. View at Publisher · View at Google Scholar · View at Scopus
  17. K. A. Kang, J. S. Kim, and J. W. Hyun, “KIOM-4 protects RINm5F pancreatic β-cells against streptozotocin induced oxidative stress in vitro,” Biotechnology and Bioprocess Engineering, vol. 13, no. 2, pp. 150–157, 2008. View at Publisher · View at Google Scholar · View at Scopus
  18. K. A. Kang, J. S. Kim, R. Zhang et al., “Protective mechanism of KIOM-4 against streptozotocin induced diabetic cells: Involvement of heme oxygenase-1,” Biotechnology and Bioprocess Engineering, vol. 14, no. 3, pp. 295–301, 2009. View at Publisher · View at Google Scholar · View at Scopus
  19. K. A. Kang, J. S. Kim, and R. Zhang, “KIOM-4 protects against oxidative stress-induced mitochondrial damage in pancreatic β-cells via its antioxidant effects,” Evidence-Based Complementary and Alternative Medicine. In press.
  20. D. Mathis, L. Vence, and C. Benoist, “β-cell death during progression to diabetes,” Nature, vol. 414, no. 6865, pp. 792–798, 2001. View at Publisher · View at Google Scholar · View at Scopus
  21. E. V. Maytin and J. F. Habener, “Transcription factors C/EBPα, C/EBPβ, and CHOP (Gadd153) expressed during the differentiation program of keratinocytes in vitro and in vivo,” Journal of Investigative Dermatology, vol. 110, no. 3, pp. 238–246, 1998. View at Publisher · View at Google Scholar · View at Scopus
  22. B. Heller, Z. Q. Wang, E. F. Wagner et al., “Inactivation of the poly(ADP-ribose) polymerase gene affects oxygen radical and nitric oxide toxicity in islet cells,” The Journal of Biological Chemistry, vol. 270, no. 19, pp. 11176–11180, 1995. View at Publisher · View at Google Scholar · View at Scopus
  23. D. L. Eizirik and T. Mandrup-Poulsen, “A choice of death—the signal-transduction of immune-mediated beta-cell apoptosis,” Diabetologia, vol. 44, no. 12, pp. 2115–2133, 2001. View at Publisher · View at Google Scholar · View at Scopus
  24. K. Mori, “Tripartite management of unfolded proteins in the endoplasmic reticulum,” Cell, vol. 101, no. 5, pp. 451–454, 2000. View at Google Scholar · View at Scopus
  25. R. J. Kaufman, D. Scheuner, M. Schröder et al., “The unfolded protein response in nutrient sensing and differentiation,” Nature Reviews Molecular Cell Biology, vol. 3, no. 6, pp. 411–421, 2002. View at Publisher · View at Google Scholar · View at Scopus
  26. S. Oyadomari, E. Araki, and M. Mori, “Endoplasmic reticulum stress-mediated apoptosis in pancreatic β-cells,” Apoptosis, vol. 7, no. 4, pp. 335–345, 2002. View at Publisher · View at Google Scholar · View at Scopus
  27. E. Araki, S. Oyadomari, and M. Mori, “Endoplasmic reticulum stress and diabetes mellitus,” Internal Medicine, vol. 42, no. 1, pp. 7–14, 2003. View at Google Scholar · View at Scopus
  28. D. R. Laybutt, A. M. Preston, M. C. Åkerfeldt et al., “Endoplasmic reticulum stress contributes to beta cell apoptosis in type 2 diabetes,” Diabetologia, vol. 50, no. 4, pp. 752–763, 2007. View at Publisher · View at Google Scholar · View at Scopus
  29. J. D. Malhotra, H. Miao, K. Zhang et al., “Antioxidants reduce endoplasmic reticulum stress and improve protein secretion,” Proceedings of the National Academy of Sciences of the United States of America, vol. 105, no. 47, pp. 18525–18530, 2008. View at Publisher · View at Google Scholar · View at Scopus
  30. C. M. Haynes, E. A. Titus, and A. A. Cooper, “Degradation of misfolded proteins prevents ER-derived oxidative stress and cell death,” Molecular Cell, vol. 15, no. 5, pp. 767–776, 2004. View at Publisher · View at Google Scholar · View at Scopus
  31. J. D. Malhotra, H. Miao, K. Zhang et al., “Antioxidants reduce endoplasmic reticulum stress and improve protein secretion,” Proceedings of the National Academy of Sciences of the United States of America, vol. 105, no. 47, pp. 18525–18530, 2008. View at Publisher · View at Google Scholar · View at Scopus
  32. J. C. Wataha, C. T. Hanks, and R. G. Craig, “The in vitro effects of metal cations on eukaryotic cell metabolism,” Journal of Biomedical Materials Research, vol. 25, no. 9, pp. 1133–1149, 1991. View at Google Scholar · View at Scopus
  33. J. Carmichael, W. G. DeGraff, and A. F. Gazdar, “Evaluation of a tetrazolium-based semiautomated colorimetric assay: Assessment of chemosensitivity testing,” Cancer Research, vol. 47, no. 4, pp. 936–942, 1987. View at Google Scholar · View at Scopus
  34. G. Hajnoczky, L. D. Robb-Gaspers, M. B. Seitz, and A. P. Thomas, “Decoding of cytosolic calcium oscillations in the mitochondria,” Cell, vol. 82, no. 3, pp. 415–424, 1995. View at Google Scholar · View at Scopus
  35. S. B. Cullinan and J. A. Diehl, “Coordination of ER and oxidative stress signaling: the PERK/Nrf2 signaling pathway,” International Journal of Biochemistry and Cell Biology, vol. 38, no. 3, pp. 317–332, 2006. View at Publisher · View at Google Scholar · View at Scopus
  36. J. Savory, M. M. Herman, and O. Ghribi, “Intracellular mechanisms underlying aluminum-induced apoptosis in rabbit brain,” Journal of Inorganic Biochemistry, vol. 97, no. 1, pp. 151–154, 2003. View at Publisher · View at Google Scholar · View at Scopus
  37. M. Schröder and R. J. Kaufman, “The mammalian unfolded protein response,” Annual Review of Biochemistry, vol. 74, pp. 739–789, 2005. View at Publisher · View at Google Scholar · View at Scopus
  38. K. F. Ferri and G. Kroemer, “Organelle-specific initiation of cell death pathways,” Nature Cell Biology, vol. 3, no. 11, pp. E255–263, 2001. View at Publisher · View at Google Scholar · View at Scopus
  39. M. Abdelrahim, K. Newman, K. Vanderlaag, I. Samudio, and S. Safe, “3,3-Diindolylmethane (DIM) and its derivatives induce apoptosis in pancreatic cancer cells through endoplasmic reticulum stress-dependent upregulation of DR5,” Carcinogenesis, vol. 27, no. 4, pp. 717–728, 2006. View at Publisher · View at Google Scholar · View at Scopus
  40. H. Y. Jiang and R. C. Wek, “Phosphorylation of the α-subunit of the eukaryotic initiation factor-2 (eIF2α) reduces protein synthesis and enhances apoptosis in response to proteasome inhibition,” The Journal of Biological Chemistry, vol. 280, no. 14, pp. 14189–14202, 2005. View at Publisher · View at Google Scholar · View at Scopus
  41. M. Moenner, O. Pluquet, M. Bouchecareilh, and E. Chevet, “Integrated endoplasmic reticulum stress responses in cancer,” Cancer Research, vol. 67, no. 22, pp. 10631–10634, 2007. View at Publisher · View at Google Scholar · View at Scopus
  42. S. Oyadomari and M. Mori, “Roles of CHOP/GADD153 in endoplasmic reticulum stress,” Cell Death and Differentiation, vol. 11, no. 4, pp. 381–389, 2004. View at Publisher · View at Google Scholar · View at Scopus
  43. R. V. Rao, H. M. Ellerby, and D. E. Bredesen, “Coupling endoplasmic reticulum stress to the cell death program,” Cell Death and Differentiation, vol. 11, no. 4, pp. 372–380, 2004. View at Publisher · View at Google Scholar · View at Scopus
  44. Y. Y. Jang, J. H. Song, Y. K. Shin, E. S. Han, and C. S. Lee, “Protective effect of boldine on oxidative mitochondrial damage in streptozotocin-induced diabetic rats,” Pharmacological Research, vol. 42, no. 4, pp. 361–371, 2000. View at Publisher · View at Google Scholar · View at Scopus
  45. L. Zhang, A. Zalewski, Y. Liu et al., “Diabetes-induced oxidative stress and low-grade inflammation in porcine coronary arteries,” Circulation, vol. 108, no. 4, pp. 472–478, 2003. View at Publisher · View at Google Scholar · View at Scopus
  46. J. H. Lim, J. W. Park, S. H. Kim, Y. H. Choi, K. S. Choi, and T. K. Kwon, “Rottlerin induces pro-apoptotic endoplasmic reticulum stress through the protein kinase C-δ-independent pathway in human colon cancer cells,” Apoptosis, vol. 13, no. 11, pp. 1378–1385, 2008. View at Publisher · View at Google Scholar · View at Scopus
  47. H. P. Harding, M. Calfon, F. Urano, I. Novoa, and D. Ron, “Transcriptional and translational control in the mammalian unfolded protein response,” Annual Review of Cell and Developmental Biology, vol. 18, pp. 575–599, 2002. View at Publisher · View at Google Scholar · View at Scopus
  48. K. Zhang and R. J. Kaufman, “Signaling the unfolded protein response from the endoplasmic reticulum,” The Journal of Biological Chemistry, vol. 279, no. 25, pp. 25935–25938, 2004. View at Publisher · View at Google Scholar · View at Scopus
  49. M. Schröder and R. J. Kaufman, “The mammalian unfolded protein response,” Annual Review of Biochemistry, vol. 74, pp. 739–789, 2005. View at Publisher · View at Google Scholar · View at Scopus
  50. J. Wu and R. J. Kaufman, “From acute ER stress to physiological roles of the unfolded protein response,” Cell Death and Differentiation, vol. 13, no. 3, pp. 374–384, 2006. View at Publisher · View at Google Scholar · View at Scopus
  51. X. Z. Wang, B. Lawson, J. W. Brewer et al., “Signals from the stressed endoplasmic reticulum induce C/EBP-homologous protein (CHOP/GADD153),” Molecular and Cellular Biology, vol. 16, no. 8, pp. 4273–4280, 1996. View at Google Scholar · View at Scopus
  52. M. V. Barone, A. Crozat, A. Tabaee, L. Philipson, and D. Ron, “CHOP (GADD153) and its oncogenic variant, TLS-CHOP, have opposing effects on the induction of G1/S arrest,” Genes and Development, vol. 8, no. 4, pp. 453–464, 1994. View at Google Scholar · View at Scopus
  53. M. Matsumoto, M. Minami, K. Takeda, Y. Sakao, and S. Akira, “Ectopic expression of CHOP (GADD153) induces apoptosis in M1 myeloblastic leukemia cells,” FEBS Letters, vol. 395, no. 2-3, pp. 143–147, 1996. View at Publisher · View at Google Scholar · View at Scopus
  54. T. Gotoh, S. Oyadomari, K. Mori, and M. Mori, “Nitric oxide-induced apoptosis in RAW 264.7 Macrophages is mediated by endoplasmic reticulum stress pathway involving ATF6 and CHOP,” The Journal of Biological Chemistry, vol. 277, no. 14, pp. 12343–12350, 2002. View at Publisher · View at Google Scholar · View at Scopus
  55. H. Zinszner, M. Kuroda, X. Wang et al., “CHOP is implicated in programmed cell death in response to impaired function of the endoplasmic reticulum,” Genes and Development, vol. 12, no. 7, pp. 982–995, 1998. View at Google Scholar · View at Scopus
  56. S. Oyadomari, K. Takeda, M. Takiguchi et al., “Nitric oxide-induced apoptosis in pancreatic β-cells is mediated by the endoplasmic reticulum stress pathway,” Proceedings of the National Academy of Sciences of the United States of America, vol. 98, no. 19, pp. 10845–10850, 2001. View at Publisher · View at Google Scholar · View at Scopus
  57. S. Oyadomari, A. Koizumi, K. Takeda et al., “Targeted disruption of the Chop gene delays endoplasmic reticulum stress-mediated diabetes,” The Journal of Clinical Investigation, vol. 109, no. 4, pp. 525–532, 2002. View at Publisher · View at Google Scholar · View at Scopus
  58. S. C. Pino, B. O'Sullivan-Murphy, E. A. Lidstone et al., “CHOP mediates endoplasmic reticulum stress-induced apoptosis in Gimap5-deficient T cells,” PLoS ONE, vol. 4, no. 5, Article ID e5468, 2009. View at Publisher · View at Google Scholar · View at Scopus