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Evidence-Based Complementary and Alternative Medicine
Volume 2011 (2011), Article ID 236186, 10 pages
http://dx.doi.org/10.1093/ecam/neq038
Original Article

Bacopa monniera Attenuates Scopolamine-Induced Impairment of Spatial Memory in Mice

1Department of Neurology, Post Graduate Institute of Medical Education and Research, Sector-12, Chandigarh 160012, India
2Internal Medicine, University of Texas Medical Branch, Galveston, TX 77555, USA
3Department of Biophysics, Post Graduate Institute of Medical Education and Research, Chandigarh, India

Received 31 August 2009; Accepted 31 March 2010

Copyright © 2011 Manish Kumar Saraf et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Scopolamine, an anticholinergic, is an attractive amnesic agent for discerning the action of candidate antiamnesic drugs. Bacopa monniera Linn (Syn. Brahmi) is one such antiamnesic agent that is frequently used in the ancient Indian medical system. We have earlier reported the reversal of diazepam-induced amnesia with B. monniera. In this study we wanted to test if scopolamine-induced impairment of spatial memory can also be ameliorated by B. monniera using water maze mouse model. The objective of study was to study the effect of B. monniera on scopolamine-induced amnesia. We employed Morris water maze scale to test the amnesic effect of scopolamine and its reversal by B. monniera. Rotarod test was conducted to screen muscle coordination activity of mice. Scopolamine significantly impaired the acquisition and retrieval of memory producing both anterograde and retrograde amnesia. Bacopa monniera extract was able to reverse both anterograde and retrograde amnesia. We propose that B. monniera's effects on cholinergic system may be helpful for developing alternative therapeutic approaches for the treatment of Alzheimer's disease.