Bacopa monniera Attenuates Scopolamine-Induced Impairment of Spatial Memory in Mice
Figure 1
Effect of B. monniera on scopolamine-induced anterograde amnesia. In acquisition trials, each value represents mean ± SEM. Control group shows significant gradual reduction in escape latency time with acquisition days as compared with Day 1 ELT. “a" indicates significance at P < .05 of particular day’s ELT (i.e., ELT of Days 2–6) versus ELT on Day 1, here data were analyzed using one-way ANOVA followed by Dunnett’s test. (a) 5% Tween 80 does not affect normal acquisition as compared to control group. Similarly, B. monniera (120 mg kg−1 oral) does not affect normal acquisition as compared to control group and Tween 80 group. (b) Scopolamine significantly impaired the gradual reduction in ELT with acquisition days at dose of 1, 0.5 and 0.1 mg kg−1 as compared to control group and Tween 80 group. We compared the ELT of treated group with control’s ELT or 5% Tween 80 ELT in each time point (i.e., Days 1–6). “b" indicates P < .05 versus ELT of control group for the same day. “c" indicates P < .05 versus ELT of 5% Tween 80 group for the same day. Here data were analyzed by ANOVA followed by least significance difference (LSD) test. (c) and (d) B. monniera (120 mg kg−1 oral) significantly attenuated scopolamine (0.5 and 0.1 mg kg−1)-induced impairment of decrease in ELT as compared with respective scopolamine-treated groups. We compared the ELT of B. monniera-treated group with scopolamine’s ELT in each time point (i.e., Days 1–6). “d" indicates significance of ELT versus same day’s ELT of scopolamine (0.5 mg kg−1 oral) group. “e" indicates significance of ELT versus same day’s ELT of scopolamine (0.1 mg kg−1 oral) group. Here data were analyzed by ANOVA followed by LSD post hoc test.
