Evidence-Based Complementary and Alternative Medicine / 2011 / Article / Tab 6

Original Article

Prescriptions of Chinese Herbal Medicines for Insomnia in Taiwan during 2002

Table 6

Summary of major constituents and pharmacologic activities of Chinese single herbs prescribed for insomnia with sedative and hypnotic effects.

Chinese single herb (generic name)Major constituentPharmacologic activity

Z. spinosaSpinosin and jujubosidesIncreases the hexobarbital-sleeping time and decreases the locomotor activity [22]
Jujuboside AInhibits the glutamate-mediated excitatory signal pathway in the hippocampus [23]
SaponinsDecreases monoaminergic system activity [24]
Sanjoinine ARegulates GABA-ergic systems and further increases the sleeping time and decreases the sleep latency induced by pentobarbital [25]
Polygala tenuifolia3,4,5-Trimethoxycinnamic acidSuppresses norepinephrine in the locus coeruleus of rats [26]
Salvia miltiorrhizaMiltironeCentral benzodiazepine receptor partial agonist [27]
Stephania tetrandriaTetrandrineEffect on serotonergic system [28]
Poria cocosErgosteroneEnhances the secretion of the cytokines, interleukin-1β and TNF-α, which enhances non-rapid eye movement sleep [29, 30]

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