Red Mold Rice Mitigates Oral Carcinogenesis in 7,12-Dimethyl-1,2-Benz[a]anthracene-Induced Oral Carcinogenesis in Hamster
Figure 6
The correlations of RMRE inhibiting ROS, NO and PG levels in DMBA-induced oral tumor model. iNOS expression induced NO generation and high NO levels might lead to oral squamous cell carcinoma development. On the other hand, COX-2 expression promoted PG synthesis, and high PG expression was increased in oral SCC tissue as compared with normal tissue. In this study, RMRE treatment had pharmacological inhibition of ROS, NO and PG in vivo. It might be a possible strategy for oral cancer prevention.
