A Chinese Herbal Decoction, Dang Gui Bu Xue Tang, Prepared from Radix Astragali and Radix Angelicae sinensis, Ameliorates Insulin Resistance Induced by A High-Fructose Diet in Rats

Table 1

General characteristics of fructose chow-fed rats after 2 weeks of treatment.

Characteristics	Standard chow-fed	Fructose chow-fed
	Vehicle	Vehicle	DBT (g kg^−1 per day)			Rosiglitazone
			0.5	1.5	2.5
Body weight (g/rat)	248.7 ± 9.8	266.8 ± 8.7	263.4 ± 8.4	258.5 ± 9.6	260.9 ± 9.4	302.3 ± 10.1^a,c
Plasma glucose (mg dL^−1)	92.3 ± 6.1^d	134.5 ± 7.2^b	128.4 ± 6.4^b	120.7 ± 5.8^b	116.4 ± 5.1^a,c	106.3 ± 5.6^a,c
Plasma insulin (𝜇U mL^−1)	21.8 ± 5.3^d	50.3 ± 4.7^b	49.5 ± 5.4^b	48.8 ± 5.6^b	48.1 ± 4.9^b	30.4 ± 5.8^d
Plasma triglyceride (mg dL^−1)	97.4 ± 9.4^d	325.2 ± 12.1^b	319.7 ± 10.7^b	312.3 ± 11.8^b	308.6 ± 12.4^b	174.2 ± 10.5^b,d
Plasma cholesterol (mg dL^−1)	85.4 ± 6.3	90.6 ± 5.9	86.5 ± 5.1	84.2 ± 6.7	83.4 ± 5.3	78.3 ± 4.7
HOMA-IR score	4.9 ± 0.7^d	16.7 ± 1.3^b	15.6 ± 0.9^b	14.5 ± 1.0^b	13.8 ± 1.1^b	7.9 ± 0.8^b,c
ISIcomp	3.63 ± 0.18^d	0.92 ± 0.14^b	1.12 ± 0.19^b	1.32 ± 0.15^b,c	1.53 ± 0.17^b,c	2.21 ± 0.15^a,c

DBT was dissolved in distilled water for oral administration at the desired doses in a volume of 10 mL kg⁻¹ once a day into rats receiving 6 weeks of fructose chow feeding. Rosiglitazone was also given by oral gavage (4 mg kg⁻¹ per day) to the separate groups of the fructose chow-fed rats. The vehicle (distilled water) used to dissolve the tested medications was given at the same volume. ISIcomp was calculated after a 2 h OGTT. Values (mean ± SD) were obtained from seven rats. ^a𝑃<.05 and ^b𝑃<.01 compared with the values of vehicle-treated standard chow-fed rats in each group, respectively. ^c𝑃<.05 and ^d𝑃<.01 compared with the values of vehicle-treated fructose chow-fed rats in each group, respectively.