A Chinese Herbal Decoction, Dang Gui Bu Xue Tang, Prepared from Radix Astragali and Radix Angelicae sinensis, Ameliorates Insulin Resistance Induced by A High-Fructose Diet in Rats

Table 2

Quantification of the specific insulin signaling proteins in soleus muscles of fructose chow-fed rats after 14-day treatment with DBT or rosiglitazone.

Relative units	Standard chow-fed	Fructose chow-fed
	Vehicle	Vehicle	DBT (2.5 g kg^−1 per day)	Rosiglitazone (4 mg kg^−1 per day)
IR	1.00 ± 0.06	1.01 ± 0.06	0.98 ± 0.09	1.01 ± 0.07
IRS-1	1.01 ± 0.05^d	0.48 ± 0.07^b	0.78 ± 0.08^a,c	0.92 ± 0.06^d
PI 3 K (p85)	1.03 ± 0.06^d	0.49 ± 0.05^b	0.81 ± 0.06^a,d	0.94 ± 0.05^d
Akt	1.02 ± 0.04^d	0.43 ± 0.06^b	0.76 ± 0.05^a,c	0.93 ± 0.08^d
AS160	1.01 ± 0.05^d	0.41 ± 0.07^b	0.68 ± 0.04^a,c	0.96 ± 0.09^d
GLUT 4	1.00 ± 0.08^d	0.89 ± 0.09	0.95 ± 0.07	0.97 ± 0.06

DBT or rosiglitazone was dissolved in distilled water for oral administration at the desired doses in a volume of 10 mL kg⁻¹ once a day into rats receiving 6 weeks of fructose chow feeding. The vehicle (distilled water) used to dissolve the tested medications was given at the same volume. Values (mean ± SD) were obtained from each group of five animals. ^a𝑃<.05 and ^b𝑃<.01 compared with the values of vehicle-treated standard chow-fed rats in each group, respectively. ^c𝑃<.05 and ^d𝑃<.01 compared with the values of vehicle-treated fructose chow-fed rats in each group, respectively.