Bufalin Induces Reactive Oxygen Species Dependent Bax Translocation and Apoptosis in ASTC-a-1 Cells

Figure 7

Schematic representation of the bufalin-induced apoptotic pathway in ASTC-a-1 cells. Once engaged by bufalin, two signal pathways are activated. One is the death receptor-mediated pathway and the other is the mitochondrion pathway. Omi/HtrA2: high temperature requirement protein A2; Smac/Diablo: second mitochondria derived activator of caspase/direct inhibitor of an apoptosis-binding protein; AIF: apoptosis inducing factor.