Gastroprotective Effect of Ginger Rhizome (Zingiber officinale) Extract: Role of Gallic Acid and Cinnamic Acid in H⁺, K⁺-ATPase/H. pylori Inhibition and Anti-Oxidative Mechanism

Table 3

Gastric mucin and H⁺, K⁺-ATPase levels in healthy, ulcerated and protected rats (𝑛=6) mean ± SD.

Group (𝑛=6)	Mucin content (mg g^−1)	H^+, K^+-ATPase μmol Pi released mg^−1 h^−1
Healthy	62.05^d±5.1	0.721^a±0.02
Swim stress-induced ulcer model
Swim stress induced	18.42^a±3.4	2.610^d±0.21
GRAE 100 mg kg^−1 b.w.	43.36^b±3.6	1.316^c±0.18
GRAE 200 mg kg^−1 b.w.	48.41^b,c±3.4	0.831^a±0.14
Lansoprazole 30 mg kg^−1 b.w.	35.14^b±2.4	1.220^b±0.12
Ethanol stress-induced ulcer model
Ethanol stress induced	22.37^a±2.3	2.318^c±0.24
GRAE 100 mg kg^−1 b.w.	36.32^b±3.6	1.213^b±0.26
GRAE 200 mg kg^−1 b.w.	46.54^c±3.8	0.793^a±0.08
Lansoprazole 30 mg kg^−1 b.w.	33.23^b,c±2.4	1.240^b±0.12

Different letters “a” to “d” in the column represents that values are significantly different when compared between ulcer induced with healthy control and GRAE/lansoprazole-treated groups. Range was provided by Duncan multiple test at 𝑃<.05. ^aLess significant; ^bModerately significant; ^cVery significant and ^dMost significant.