Inhibitory Effects of Ethyl Acetate Extract of Andrographis paniculata on NF-κB Trans-Activation Activity and LPS-Induced Acute Inflammation in Mice
Figure 4
Morphological changes in mouse lung sections on LPS induction of sepsis with/without treatment with EtOAc extract of AP. Histopathologic analysis was performed on hematoxylin and eosin (H. E.) stained sections of lung at 6 h after LPS administration. (a) PBS group was received an i.p. injection of PBS buffer; (b) LPS group, received an i.p. injection of 15 mg kg−1 BW LPS severe lung edema and inflammatory cells infiltration (arrow) were observed in this group; (c) PDTC + LPS group, received an i.p. injection of 50 mg kg−1 BW PDTC 1 h before LPS administration; (d) AP 1 group, was given an oral dose of 0.78 mg kg−1 BW AP; (e) AP 2 group, was given an oral dose of 1.56 mg kg−1 BW AP; (f) AP 3 group, was given an oral dose of 3.12 mg kg−1 BW AP. (magnification 400x).
