Excoecarianin, Isolated from Phyllanthus urinaria Linnea, Inhibits Herpes Simplex Virus Type 2 Infection through Inactivation of Viral Particles

Table 1

The effect of treatment time on the antiviral activity of excoecarianin.

Time periods of compound addition	Percentage of inhibition
	Excoecarianin	ACV
Before infection
–6	0.0 ± 0.0	0.0 ± 0.0
–2	0.0 ± 0.0	15.0 ± 7.6
During infection
0	56.2 ± 7.3*	95.4 ± 1.7*
After infection
2	22.6 ± 10.2	92.6 ± 5.0*
4	31.2 ± 19.2	94.9 ± 4.7*

Excoecarianin and ACV were tested at a concentration of 1.5 and 5 μM, respectively; Data were mean ± SD of three independent experiments; *P < .05 (compared between control and tested compound).