Excoecarianin, Isolated from Phyllanthus urinaria Linnea, Inhibits Herpes Simplex Virus Type 2 Infection through Inactivation of Viral Particles

Table 2

The effect of excoecarianin against HSV-2 infectivity.

	Concentration (μM)	Percentage control of viral infectivity
Control	0	100.0 ± 0.0
Excoecarianin	0.1	91.6 ± 7.4
	0.5	98.8 ± 2.1
	1.0	96.2 ± 6.6
	1.5	61.3 ± 7.8*
	2.0	27.7 ± 7.9*
	2.5	36.3 ± 10.8*
	4.0	1.5 ± 0.1*
ACV	0.5	100.0 ± 0.5
	2.5	92.8 ± 6.5
	5.0	92.9 ± 4.9
	10.0	91.7 ± 8.2

Excoecarianin was mixed with HSV-2 at 37°C for 6 h before the residual viral titer was determined by plaque assay; Values were mean ± SD of three independent experiments; *P < .05 (compared between control and tested compound).