Table of Contents Author Guidelines Submit a Manuscript
Evidence-Based Complementary and Alternative Medicine
Volume 2011 (2011), Article ID 292873, 9 pages
http://dx.doi.org/10.1155/2011/292873
Research Article

CI431, an Aqueous Compound from Ciona intestinalis L., Induces Apoptosis through a Mitochondria-Mediated Pathway in Human Hepatocellular Carcinoma Cells

1Institute of Oceanology, Chinese Academy of Sciences, Qingdao 266071, China
2Graduate University, Chinese Academy of Sciences, Beijing 100049, China
3College of Chemical Engineering, Qingdao University of Science and Technology, Qingdao 266042, China

Received 21 January 2011; Accepted 21 May 2011

Copyright © 2011 Linyou Cheng et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. J. W. Blunt, B. R. Copp, W. P. Hu, M. H. G. Munro, P. T. Northcote, and M. R. Prinsep, “Marine natural products,” Natural Product Reports, vol. 26, no. 2, pp. 170–244, 2009. View at Publisher · View at Google Scholar · View at Scopus
  2. J. W. Blunt, B. R. Copp, W. Hu, M. H. G. Munro, P. T. Northcote, and M. R. Prinsep, “Marine natural products,” Natural Product Reports, vol. 25, no. 1, pp. 35–94, 2008. View at Publisher · View at Google Scholar · View at Scopus
  3. D. J. Newman and G. M. Cragg, “Marine natural products and related compounds in clinical and advanced preclinical trials,” Journal of Natural Products, vol. 67, no. 8, pp. 1216–1238, 2004. View at Publisher · View at Google Scholar · View at Scopus
  4. M. D. Lebar, J. L. Heimbegner, and B. J. Baker, “Cold-water marine natural products,” Natural Product Reports, vol. 24, no. 4, pp. 774–797, 2007. View at Publisher · View at Google Scholar · View at Scopus
  5. K. L. Rinehart, “Antitumor compounds from tunicates,” Medicinal Research Reviews, vol. 20, no. 1, pp. 1–27, 2000. View at Publisher · View at Google Scholar · View at Scopus
  6. D. J. Newman and G. M. Cragg, “Advanced preclinical and clinical trials of natural products and related compounds from marine sources,” Current Medicinal Chemistry, vol. 11, no. 13, pp. 1693–1713, 2004. View at Google Scholar · View at Scopus
  7. K. L. Rinehart, J. B. Gloer, J. C. Carter, S. A. Mizsak, and T. A. Scahill, “Structures of the didemnins, antiviral and cytotoxic depsipeptides from a Caribbean tunicate,” Journal of the American Chemical Society, vol. 103, no. 7, pp. 1857–1859, 1981. View at Google Scholar · View at Scopus
  8. J. L. Urdiales, P. Morata, I. N. de Castro, and F. Sánchez-Jiménez, “Antiproliferative effect of dehydrodidemnin B (DDB), a depsipeptide isolated from Mediterranean tunicates,” Cancer Letters, vol. 102, no. 1-2, pp. 31–37, 1996. View at Publisher · View at Google Scholar
  9. M. C. Edler, A. M. Fernandez, P. Lassota, C. M. Ireland, and L. R. Barrows, “Inhibition of tubulin polymerization by vitilevuamide, a bicyclic marine peptide, at a site distinct from colchicine, the vinca alkaloids, and dolastatin 10,” Biochemical Pharmacology, vol. 63, no. 4, pp. 707–715, 2002. View at Publisher · View at Google Scholar · View at Scopus
  10. N. Lindquist, W. Fenical, G. D. Van Duyne, and J. Clardy, “Isolation and structure determination of diazonamides A and B, unusual cytotoxic metabolites from the marine ascidian Diazona chinensis,” Journal of the American Chemical Society, vol. 113, no. 6, pp. 2303–2304, 1991. View at Google Scholar · View at Scopus
  11. K. Rinehart, T. G. Holt, N. L. Fregeau et al., “Ecyeinascidin 729, 743, 759A, and 770: potent antutumor agents from the Caribbean tunicate Ecteinascidia turbinata,” Journal of Organic Chemistry, vol. 55, no. 15, pp. 4512–4515, 1990. View at Publisher · View at Google Scholar
  12. M. Zhang, H. Zhang, C. Sun et al., “Targeted constitutive activation of signal transducer and activator of transcription 3 in human hepatocellular carcinoma cells by cucurbitacin B,” Cancer Chemotherapy and Pharmacology, vol. 63, no. 4, pp. 635–642, 2009. View at Publisher · View at Google Scholar · View at Scopus
  13. M. A. Avila, C. Berasain, B. Sangro, and J. Prieto, “New therapies for hepatocellular carcinoma,” Oncogene, vol. 25, no. 27, pp. 3866–3884, 2006. View at Publisher · View at Google Scholar · View at Scopus
  14. J. Martin and J. F. Dufour, “Tumor suppressor and hepatocellular carcinoma,” World Journal of Gastroenterology, vol. 14, no. 11, pp. 1720–1733, 2008. View at Publisher · View at Google Scholar · View at Scopus
  15. N. J. Gusani, Y. Jiang, E. T. Kimchi, K. F. Staveley-O'Carroll, H. Cheng, and J. A. Ajani, “New pharmacological developments in the treatment of hepatocellular cancer,” Drugs, vol. 69, no. 18, pp. 2533–2540, 2009. View at Publisher · View at Google Scholar · View at Scopus
  16. A. I. Gomaa, S. A. Khan, M. B. Toledano, I. Waked, and S. D. Taylor-Robinson, “Hepatocellular carcinoma: epidemiology, risk factors and pathogenesis,” World Journal of Gastroenterology, vol. 14, no. 27, pp. 4300–4308, 2008. View at Publisher · View at Google Scholar · View at Scopus
  17. T. Wang, W. Huang, and T. Chen, “Baclofen, a GABAB receptor agonist, inhibits human hepatocellular carcinoma cell growth in vitro and in vivo,” Life Sciences, vol. 82, no. 9-10, pp. 536–541, 2008. View at Publisher · View at Google Scholar · View at Scopus
  18. M. Thomas, “Molecular targeted therapy for hepatocellular carcinoma,” Journal of Gastroenterology, vol. 44, no. 19, pp. 136–141, 2009. View at Publisher · View at Google Scholar · View at Scopus
  19. Q. J. He, B. Yang, Y. J. Lou, and R. Y. Fang, “Contragestazol (DL111-IT) inhibits proliferation of human androgen-independent prostate cancer cell line PC3 in vitro and in vivo,” Asian Journal of Andrology, vol. 7, no. 4, pp. 389–393, 2005. View at Publisher · View at Google Scholar · View at Scopus
  20. H. L. Xu, Y. Inagaki, F. S. Wang, N. Kokudo, M. Nakata, and W. Tang, “Effect of benzyl-N-acetyl-α-galactosaminide on KL-6 mucin expression and invasive properties of a human pancreatic carcinoma cell line,” Drug Discoveries & Therapeutics, vol. 2, pp. 282–285, 2008. View at Google Scholar
  21. P. N. Chen, S. C. Chu, H. L. Chiou, C. L. Chiang, S. F. Yang, and Y. S. Hsieh, “Cyanidin 3-glucoside and peonidin 3-glucoside inhibit tumor cell growth and induce apoptosis in vitro and suppress tumor growth in vivo,” Nutrition and Cancer, vol. 53, no. 2, pp. 232–243, 2005. View at Publisher · View at Google Scholar · View at Scopus
  22. C. Riccardi and I. Nicoletti, “Analysis of apoptosis by propidium iodide staining and flow cytometry,” Nature Protocols, vol. 1, no. 3, pp. 1458–1461, 2006. View at Publisher · View at Google Scholar · View at Scopus
  23. S. K. Mantena, S. D. Sharma, and S. K. Katiyar, “Berberine, a natural product, induces G1-phase cell cycle arrest and caspase-3-dependent apoptosis in human prostate carcinoma cells,” Molecular Cancer Therapeutics, vol. 5, no. 2, pp. 296–308, 2006. View at Publisher · View at Google Scholar · View at Scopus