Table of Contents Author Guidelines Submit a Manuscript
Evidence-Based Complementary and Alternative Medicine
Volume 2011 (2011), Article ID 307121, 7 pages
http://dx.doi.org/10.1093/ecam/nep030
Review Article

Lyprinol—Is It a Useful Anti-Inflammatory Agent?

School of Life Sciences, Queensland University of Technology, GPO Box 2434, Brisbane, QLD 4001, Australia

Received 25 September 2008; Accepted 25 March 2009

Copyright © 2011 Sheila A. Doggrell. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. Lyprinol, Available at http://www.lyprinol.com.
  2. Social Issues Research Centre, September 2008, http://www.sirc.org/media/mediasept2399.html.
  3. Claims of media manipulation after NZ diet food frenzy, September 2008, http://www.abc.net.au/am/stories/s41055.htm.
  4. Introductory information about Lyprinol, September 2008, http://www.baranboost.com/lyprinol_presenter_english.pdf.
  5. Lyprinol, September 2008, http://www.lyprinol-arthritis.com/.
  6. Food and Drug Administration, September 2008, www.fda.gov/cder/warn/cyber/2007/UL4.pdf.
  7. Lyprinol, September 2008, www.lyprinolusa.com/.
  8. T. A. Macrides and N. Kalafatis, “Super-critical lipid extract from mussels having anti-inflammatory activity,” US Patent no. 6083536, 2000.
  9. Mobicosa capsules—a natural arthritis treatment, September 2008, http://www.naturalmobility.com.au/mobicosacapsules.html.
  10. K. J. Murphy, B. D. Mooney, N. J. Mann, P. D. Nichols, and A. J. Sinclair, “Lipid, FA, and sterol composition of New Zealand green lipped mussel (Perna canaliculus) and Tasmanian blue mussel (Mytilus edulis),” Lipids, vol. 37, no. 6, pp. 587–595, 2002. View at Google Scholar · View at Scopus
  11. A. P. Treschow, L. D. Hodges, P. F. A. Wright, P. M. Wynne, N. Kalafatis, and T. A. Macrides, “Novel anti-inflammatory ω-3 PUFAs from the New Zealand green-lipped mussel, Perna canaliculus,” Comparative Biochemistry and Physiology B, vol. 147, no. 4, pp. 645–656, 2007. View at Publisher · View at Google Scholar · View at Scopus
  12. M. W. Whitehouse, T. A. Macrides, N. Kalafatis, W. H. Betts, D. R. Haynes, and J. Broadbent, “Anti-inflammatory activity of a lipid fraction (Lyprinol) from the NZ green-lipped mussel,” Inflammopharmacology, vol. 5, no. 3, pp. 237–246, 1997. View at Google Scholar · View at Scopus
  13. S. McPhee, L. D. Hodges, P. F. A. Wright et al., “Anti-cyclooxygenase effects of lipid extracts from the New Zealand green-lipped mussel, Perna canaliculus,” Comparative Biochemistry and Physiology B, vol. 146, no. 3, pp. 346–356, 2007. View at Publisher · View at Google Scholar · View at Scopus
  14. S. Mani and J. W. Lawson, “In vitro modulation of inflammatory cytokine and IgG levels by extracts of Perna canaliculus,” BMC Complementary and Alternative Medicine, vol. 6, article no. 1, 2006. View at Publisher · View at Google Scholar · View at Scopus
  15. T. Kosuge, K. Tsuji, H. Ishida, and T. Yamaguchi, “Isolation of an anti-histaminic substance from green-lipped mussel (Perna canaliculus),” Chemical and Pharmaceutical Bulletin, vol. 34, no. 11, pp. 4825–4828, 1986. View at Google Scholar · View at Scopus
  16. C.-H. Lee, J. H.-K. Lum, C. K.-C. Ng et al., “Pain controlling and Cytokine-regulating effects of lyprinol, a lipid extract of perna canaliculus, in a rat Adjuvant-induced arthritis model,” Evidence-Based Complementary and Alternative Medicine, vol. 6, no. 2, pp. 239–245, 2009. View at Publisher · View at Google Scholar · View at Scopus
  17. B. R. Lawson, S. M. Belkowski, J. F. Whitesides, P. Davis, and J. W. Lawson, “Immunomodulation of murine collagen-induced arthritis by N, N-dimethylglycine and a preparation of Perna canaliculus,” BMC Complementary and Alternative Medicine, vol. 7, article no. 20, 2007. View at Publisher · View at Google Scholar · View at Scopus
  18. C.-H. Lee, Y. K.-C. Butt, M.-S. Wong, and S. C.-L. Lo, “Differential protein expression induced by a lipid extract of Perna canaliculus in splenocytes of rats with adjuvant-induced arthritis,” Inflammopharmacology, vol. 16, no. 4, pp. 188–194, 2008. View at Publisher · View at Google Scholar · View at Scopus
  19. M. W. Whitehouse and D. E. Butters, “Combination anti-inflammatory therapy: synergism in rats of NSAIDs/corticosteroids with some herbal/animal products,” Inflammopharmacology, vol. 11, no. 4–6, pp. 453–464, 2003. View at Publisher · View at Google Scholar · View at Scopus
  20. M. W. Whitehouse, “Anti-TNF-α therapy for chronic inflammation: reconsidering pentoxifylline as an alternative to therapeutic protein drugs,” Inflammopharmacology, vol. 12, no. 3, pp. 223–227, 2004. View at Publisher · View at Google Scholar · View at Scopus
  21. M. Singh, L. D. Hodges, P. F. A. Wright et al., “The CO2-SFE crude lipid extract and the free fatty acid extract from Perna canaliculus have anti-inflammatory effects on adjuvant-induced arthritis in rats,” Comparative Biochemistry and Physiology B, vol. 149, no. 2, pp. 251–258, 2008. View at Publisher · View at Google Scholar · View at Scopus
  22. D. Tenikoff, K. J. Murphy, M. Le, P. R. Howe, and G. S. Howarth, “Lyprinol (stabilised lipid extract of New Zealand green-lipped mussel): a potential preventative treatment modality for inflammatory bowel disease,” Journal of gastroenterology, vol. 40, no. 4, pp. 361–365, 2005. View at Google Scholar · View at Scopus
  23. D. M. Torres, K. L. Tooley, R. N. Butler, C. L. Smith, M. S. Geier, and G. S. Howarth, “Lyprinol only partially improves indicators of small intestinal integrity in a rat model of 5-fluorouracil-induced mucositis,” Cancer Biology and Therapy, vol. 7, no. 2, pp. 295–302, 2008. View at Google Scholar · View at Scopus
  24. I.-A. Shiels and M.-W. Whitehouse, “Lyprinol: anti-inflammatory and uterine-relaxant activities in rats, with special reference to a model for dysmenorrhoea,” Allergie et Immunologie, vol. 32, no. 7, pp. 279–283, 2000. View at Google Scholar · View at Scopus
  25. L. M. Bui and T. L. Bierer, “Influence of green-lipped mussel (Perna canaliculus) in alleviating signs of arthritis is dogs,” Veterinary Therapeutics, vol. 2, no. 2, pp. 101–111, 2001. View at Google Scholar · View at Scopus
  26. B. Dobenecker, Y. Beetz, and E0 Kienzle, “A placebo-controlled double-blind study on the effect of nutraceuticals (chondroitin sulphate and mussel extract) in dogs with joint diseases as perceived by their owners,” Journal of Nutrition, vol. 132, pp. 1690S–1691S, 2002. View at Google Scholar
  27. B. Pollard, W. G. Guilford, K. L. Ankenbauer-Perkins, and D. Hedderley, “Clinical efficacy and tolerance of an extract of green-lipped mussel (Perna canaliculus) in dogs presumptively diagnosed with degenerative joint disease,” New Zealand Veterinary Journal, vol. 54, no. 3, pp. 114–118, 2006. View at Google Scholar · View at Scopus
  28. A. Hielm-Björkman, R.-M. Tulamo, H. Salonen, and M. Raekallio, “Evaluating complementary therapies for canine osteoarthritis part I: green-lipped mussel (Perna canaliculus),” Evidence-Based Complementary and Alternative Medicine, vol. 6, no. 3, pp. 365–373, 2009. View at Publisher · View at Google Scholar · View at Scopus
  29. S. L. M. Gibson and R. G. Gibson, “The treatment of arthritis with a lipid extract of Perna canaliculus: a randomized trial,” Complementary Therapies in Medicine, vol. 6, no. 3, pp. 122–126, 1998. View at Publisher · View at Google Scholar · View at Scopus
  30. N. Babul, R. Noveck, H. Chipman, S. H. Roth, T. Gana, and K. Albert, “Efficacy and safety of extended-release, once-daily tramadol in chronic pain: a randomized 12-week clinical trial in osteoarthritis of the knee,” Journal of Pain and Symptom Management, vol. 28, no. 1, pp. 59–71, 2004. View at Publisher · View at Google Scholar · View at Scopus
  31. K. Pavelka, T. Trč, K. Karpaš et al., “The efficacy and safety of diacerein in the treatment of painful osteoarthritis of the knee,” Arthritis and Rheumatism, vol. 56, pp. 4055–4064, 2007. View at Google Scholar
  32. K. G. A. Yang, N. J. H. Raijmakers, E. R. A. van Arkel et al., “Autologous interleukin-1 receptor antagonist improves function and symptoms in osteoarthritis when compared to placebo in a prospective randomized controlled trial,” Osteoarthritis and Cartilage, vol. 16, no. 4, pp. 498–505, 2008. View at Publisher · View at Google Scholar · View at Scopus
  33. S. H. Cho, Y. B. Jung, S. C. Seong et al., “Clinical efficacy and safety of Lyprinol®, a patented extract from New Zealand green-lipped mussel (Perna Canaliculus) in patients with osteoarthritis of the hip and knee: a multicenter 2-month clinical trial,” European Annals of Allergy and Clinical Immunology, vol. 35, no. 6, pp. 212–216, 2003. View at Google Scholar · View at Scopus
  34. C. S. Lau, P. K. Y. Chiu, E. M. Y. Chu, I. Y. M. Cheny, W. M. Tang, and R. Y. K. Man, “Halpern GM: treatment of knee osteoporosis with Lyprinol®, lipid extract of the green-lipped mussel – a double-blind placebo-controlled study,” Progress in Nutrition, vol. 6, pp. 17–31, 2004. View at Google Scholar
  35. J. Gruenwald, H. J. Graubaum, K. Hansen, and B. Grube, “Efficacy and tolerability of a combination of Lyprinol and high concentrations of EPA and DHA in inflammatory rheumatoid disorders,” Advances in Therapy, vol. 21, pp. 197–201, 2004. View at Google Scholar
  36. A. Emelyanov, G. Fedoseev, O. Krasnoschekova, A. Abulimity, T. Trendeleva, and P. J. Barnes, “Treatment of asthma with lipid extract of New Zealand green-lipped mussel: a randomised clinical trial,” European Respiratory Journal, vol. 20, pp. 596–600, 2002. View at Google Scholar
  37. P. C. Calder, “n-3 polyunsaturated fatty acids, inflammation and inflammatory disease,” American Journal of Clinical Nutrition, vol. 83, 6 supplement, pp. 1505S–1519S, 2006. View at Google Scholar
  38. R. J. Goldberg and J. Katz, “A meta-analysis of the analgesic effects of omega-3 polyunsaturated fatty acid supplementation for inflammatory joint pain,” Pain, vol. 129, pp. 210–223, 2006. View at Google Scholar
  39. B. G. Feagan, W. J. Sandborn, U. Mittmann, S. Bar-Meir, G. D’Haens, M. Bradette et al., “Omega-3 free fatty acids for the maintenance of remission in Crohn disease; the EPIC randomized controlled trial,” Journal of the American Medical Association, vol. 299, pp. 1690–1697, 2008. View at Google Scholar
  40. M. De Ley, R. de Vos, D. W. Hommes, and P. Stokkers, “Fish oil for induction of remission in ulcerative colitis,” Cochrane Database of Systematic Reviews, vol. 4, article CD005986, 2007. View at Google Scholar