Evidence-Based Complementary and Alternative Medicine

Research Article

Toxicity and Neuropharmacological Effects of Elenine

Table 1

General activity and time-dose response summary showing the average data score.
Time after drug (min)
3060120180
Dose C102040C102040C102040C102040
Behavioural
(1) Spontaneous activity
 Body position42.8*2*1.8*42.6*2.8*1.6*42.2*1.8*1.6*42.2*1.8*1.6*
 Locomotor activity43*2*1.8*42*1.6*1.5*42*1.5*1.5*42*1.5*1.5*
(2) Motor-affective response
 Transfer arousal43.1*2.5*2.3*42.7*2.3*2.2*42.4*2.2*2.2*43*2*2*
 Touch escape43.6*2.3*2*43.3*2.3*1.8*43*2*1.8*43*2*1.8*
 Positional passivity002*1.9*402*1.9*402*1.9*402*1.9*
(3) Sensorimotor response
 Toe pinch43.2*2*2*43*2*1.7*43*2*1.7*43*2*1.7*
 Corneal43*2.5*2.543*2.5*2.5*43*2.5*2.5*43*2.5*2.5*
 Pinna43.43.2*2.843.4*3.2*2.8*43.4*3.2*2.8*43.4*3.2*2.8*
(4) Posture
 Tail elevation2222222222222222
Neurologic
(1) Muscle tone
 Body tone43.5*3.*3*43.2*2.8*2.6*43*2.6*2.6*43*2.6*2.6*
 Abdominal tone43.3*2.6*2.4*43*2.6*2.4*42.8*2.2*2*42.8*2.2*2*
 Limb tone43.6*3.3*3*43.6*3*3*43.6*3*3*43.6*3*3*
 Grip strength43.4*2.8*2.4*43.4*2.6*2.4*43.4*2.6*2.2*43.4*2.6*2.2*
 Wire manoeuvre00.5*0.7*1.2*00.6*0.9*1.2*00.7*0.9*1.2*40.70.9*1.2*
(2) Equilibrium and gait
 Righting reflects00.2*0.3*0.5*00.5*0.6*0.8*00.5*0.6*0.80.1*00.5*0.7*0.8*
 Hypotonic gait00.4*0.7*0.8*00.6*0.8*0.8*00.6*0.8*00.6*0.9*1*
(3) CNS excitation
 Tremors0000000000000000
 Twitches0000000000000000
 Convulsions0000000000000000
Autonomic
(1) Eyes: Palpebral closure000.4*0.6*00.4*0.5*0.6*00.4*0.5*0.6*00.4*0.5*0.6*
(2) Secretion Excitation
 Diarrhoea++++++
(3) General
 Piloerection0000000000000000
 Hypothermia+++++++++
 Respiratory rate43.8*3.6*3.4*43.8*3.6*3.4*43.8*3.6*3.4*43.8*3.6*3.4*
 Skin colour4444444444444444
(a) C, control, 10, 20, and 40 mg/Kg elenine. * versus control group.