Evaluation of the Anxiolytic Activity of NR-ANX-C (a Polyherbal Formulation) in Ethanol Withdrawal-Induced Anxiety Behavior in Rats

Table 2

Acute NR-ANX-C pretreatment reduced EW-induced anxiety behavior in elevated plus maze.

Treatment group	Number of entries into		Total arm entries	% of open/total arm entries	Time spent in (s)		Number of rears in
	Open arms	Closed arms			Open arms	Closed arms	Open arms	Closed arms
EW control	2.3±0.4	5.1±0.9	7.1±1.1	27.9±5.4	18.6±5.0	270.0±5.5	1.4±0.5	10.1±1.4
Alprazolam (0.08 mg/kg)	6.2±0.6^∗∗	7.3±0.2	13.3±0.7^∗∗	45.2±2.3^∗	81.8±12.5^∗∗	207.0±18.5^∗	5.7±0.8^∗∗	14.3±1.0
NR-ANX-C (10 mg/kg)	1.8±0.5	4.3±0.9	6.2±1.3	27.2±5.6	29.0±10.7	254.0±12.9	1.7±0.5	7.5±0.7
NR-ANX-C (20 mg/kg)	2.7±0.5	3.7±0.8	6.3±1.3	42.8±4.2	56.0±17.9	235.0±18.5	2.3±0.8	11.5±1.7
NR-ANX-C (40 mg/kg)	7.0±0.6^∗∗	8.0±0.6^∗	15.0±1.1^∗∗	48.2±2.3^∗∗	73.8±13.2^∗	215.0±11.1^∗	8.7±1.2^∗∗	13.0±0.8

Values are mean ± SEM; Statistical analysis by One-way ANOVA followed by Dunnett’s Multiple Comparison test. ^∗𝑃<.05; ^∗∗𝑃<.01.