Evaluation of the Anxiolytic Activity of NR-ANX-C (a Polyherbal Formulation) in Ethanol Withdrawal-Induced Anxiety Behavior in Rats

Table 5

Chronic NR-ANX-C pretreatment reduced EW-induced anxiety behavior in elevated plus maze.

Treatment group	Number of entries into		Total Arm entries	% of open/total arm entries	Time spent in (s)		Number of rears in
	Open arms	Closed arms			Open arms	Closed arms	Open arms	Closed arms
EW control	1.6 ± 0.4	5.7 ± 0.8	7.4 ± 1.1	19.8 ± 5.1	15.1 ± 5.7	277.0 ± 5.0	1.1 ± 0.4	10.6 ± 1.3
Alprazolam (0.08 mg/kg)	3.8 ± 0.5*	4.8 ± 0.9	8.7 ± 1.1	45.7 ± 4.2*	54.7 ± 15.1*	234.0 ± 15.1*	3.7 ± 0.6*	16.2 ± 1.5*
NR-ANX-C (10 mg/kg)	3.8 ± 0.7*	4.8 ± 0.8	8.7 ± 1.3	44.8 ± 4.2*	32.2 ± 3.4	262.0 ± 3.8	3.0 ± 0.7	10.8 ± 1.7
NR-ANX-C (20 mg/kg)	4.5 ± 0.6*	4.2 ± 0.8	8.7 ± 0.3	53.1 ± 7.9*	45.0 ± 10.0*	245.0 ± 5.7*	3.8 ± 0.8*	11.2 ± 0.9
NR-ANX-C (40 mg/kg)	4.8 ± 0.3*	4.3 ± 0.7	9.1 ± 0.9	52.74 ± 5.6*	49.7 ± 11.1*	242.0 ± 16.2*	4.8 ±1.1*	19.5 ± 0.6*

Values are mean ± SEM; Statistical analysis by One-way ANOVA followed by Dunnett’s Multiple Comparison test. ^∗𝑃<.05; ^∗∗𝑃<.01.