Effect of Hachimijiogan against Renal Dysfunction and Involvement of Hypoxia-Inducible Factor-1α in the Remnant Kidney Model

Table 3

Effect of hachimijiogan on renal functional parameters.

	s-Alb (mg/dL)	BUN (mg/dL)	s-Cre (mg/dL)	u-Pro (mg/day)	Ccr (mL/min/kg BW)	8-OHdG (ng/day)
Sham	834.8 ± 110.9	15.6 ± 1.9	0.32 ± 0.14	13.01 ± 7.29	5.03 ± 3.07	325.9 ± 106.5
Control	887.1 ± 67.4	50.6 ± 36.7**	1.44 ± 1.32**	35.34 ± 20.62**	1.88 ± 0.94**	840.4 ± 252.4**
LD-HJG	895.8 ± 25.7	42.0 ± 27.1*	0.93 ± 0.59	25.15 ± 15.32	2.13 ± 1.40**	582.9 ± 201.8^#
HD-HJG	833.9 ± 82.2	39.6 ± 25.7	0.87 ± 0.61	19.73 ± 5.41^#	2.11 ± 0.86**	550.9 ± 210.5^#
Candesartan	840.8 ± 92.5	33.8 ± 12.3	0.88 ± 0.49	15.41 ± 5.92^##	1.65 ± 0.64**	484.2 ± 171.3^##

LD-HJG: low-dose hachimijiogan; HD-HJG: high-dose hachimijiogan.
Data represent mean ± S.D. (n = 8–10).
^∗𝑃<.05, ^∗∗𝑃<.01 versus sham group.
^#𝑃<.05, ^##𝑃<.01 versus control group.