Administration of a Decoction of Sucrose- and Polysaccharide-Rich Radix Astragali (Huang Qi) Ameliorated Insulin Resistance and Fatty Liver but Affected Beta-Cell Function in Type 2 Diabetic Rats
Figure 1
Polysaccharide and sucrose are only present in the water extract of Radix Astragali (RA) (AM-W). (a) LC-ELSD chromatograms of the AM-W (a) and the ethanolic extract (AM-E) (b) with a 70-min retention time. Peak identification: 1, astragaloside II; 2, isoastragaloside I; 3, astragaloside I. (b) LC-ELSD chromatograms of the AM-W (a) and sucrose (b) with a 10-min retention time. Peak identification: 1, 2, and 3, polysaccharides; peak 4, sucrose. (c) The representative 1H NMR and 13C NMR spectra of AM-W-F1 and AM-W-F2 are illustrated. (d) Confirmation of the hypoglycemic bioactivity of the AM-W. Insulin-dependent diabetic rats were generated with an initial average glucose level at 407.2 ± 17.8 mg/dL (). The hypoglycemic effect was evaluated by determining the percentage of the initial fasting glucose level in each group. Differences at the same time point were determined by ANOVA followed by the Tukey-Kramer test. * was considered significant when compared to the control (vehicle) insulin-dependent diabetes mellitus rats.
