In Vitro Antiplasmodial Activity of Sesquiterpene Lactones from Ambrosia tenuifolia

Table 1

In vitro antiplasmodial activity, cytotoxicity and selectivity indexes of Ambrosia tenuifola extract, psilostachyin and peruvin.

Extract/Compounds	IC50 (μM)		CC50 (μM)	Selectivity Index
	P. falciparum	P. falciparum	48 h	P. falciparum	P. falciparum
	F32 strain	W2 strain		F32 strain	W2 strain
CH2Cl2 : MeOH (1 : 1)	2.0±0.09 *	n.t.	n.t.	n.c.	n.c.
Psilostachyin	2.1±0.15	6.4±0.48	24.3±0.21	11.6±0.95	3.8±0.25
Peruvin	1.1±0.09	18.9±0.95	37.9±0.34	34.4±2.40	2.0±0.15
Chloroquine	0.03±0.002	2.8±0.19	n.t.	n.c.	n.c.

n.t.: not tested; n.c.: not calculated.
*Expressed as μg/ML.