Ganoderma lucidum Polysaccharides Induce Macrophage-Like Differentiation in Human Leukemia THP-1 Cells via Caspase and p53 Activation

Figure 7

A proposed model to characterize the intricate machinery in F3-induced THP-1 cells. F3 might mimic/induce death receptor ligands such as TNF-α and TRAIL to trigger apoptosis and macrophage differentiation of leukemia cells THP-1 through caspase cascade and p53-dependent pathway.