Screening Antitumor Compounds Psoralen and Isopsoralen from Psoralea corylifolia L. Seeds

Table 2

Cytotoxic activity of fraction IV, psoralen and isopsoralen against cancer cell lines.

	Cell line
	KB	KBv200		K562	K562/ADM
	IC50 (μg/mL)	IC50 (μg/mL)	RF^a	IC50 (μg/mL)	IC50 (μg/mL)	RF^a
Psoralea corylifolia L. fraction IV	21.60	24.40	1.13	10.00	26.90	2.69
Psoralen	88.10	86.60	0.98	24.40	62.60	2.57
Isopsoralen	61.90	49.40	0.80	49.60	72.00	1.45

^aResistance factor (RF) was calculated as RF = IC₅₀(R)/IC₅₀(S); S, sensitive cell lines (KB, K562), R, multidrug-resistant cell lines (KBv200, K562/ADM), respectively.