Neuron Regeneration and Proliferation Effects of Danshen and Tanshinone IIA

Figure 5

Schematic model of the proliferative effects and nerve regeneration involving MAPK-signaling pathways in Schwann cells and peripheral neurons exposed to danshen and tanshinone IIA. Stimulation of neurons and Schwann cells with danshen and tanshinone IIA activates FGF-2 signaling, leading to the up-regulation of uPA, down-regulating of PAI-1, which in turn activated the cell cycle by increasing cyclin protein (a), (d), and (e), thereby enhancing proliferation and regeneration.