San-Huang-Xie-Xin-Tang Protects against Activated Microglia- and 6-OHDA-Induced Toxicity in Neuronal SH-SY5Y Cells

Table 1

Effects of SHXT (25, 50, 100 and 200 μg/mL) on LPS-induced nitrite, PGE₂, iROS, TNF-α and IL-1β production in BV-2 cells.

	Nitrite (μM)	PGE2 (pg/mL)	iROS (%)	TNF-α (pg/mL)	IL-1β (pg/mL)
Control	0.25 ± 0.03	14.45 ± 1.53	100	70.41 ±8. 51	10.51 ± 3.57
LPS only	3.76 ± 0.20^#	41.83 ± 2.53^#	201.52 ± 9.52^#	704.61 ± 30.53^#	68.51 ± 5.65^#
LPS + SHXT 25 μg/mL	2.96 ± 0.41	27.39 ± 2.14*	192.51 ± 8.52	650.25 ± 20.56	58.52 ± 7.24
LPS + SHXT 50 μg/mL	1.89 ± 0.34*	22.52 ± 1.95*	182.57 ± 8.50	552.53 ± 10.51*	50.14 ± 4.65*
LPS + SHXT 100 μg/mL	1.63 ± 0.21*	21.62 ± 1.52*	130.73 ± 6.25*	430.56 ± 12.86*	42.51 ± 4.64*
LPS + SHXT 200 μg/mL	1.50 ± 0.14*	14.68 ± 1.35*	109.64 ± 6.63*	263.50 ± 15.58*	26.52 ± 5.63*

Values represent the mean ± SEM from six independent experiments. ^#P <  .05 versus control, *P <  .05 versus LPS only.