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Evidence-Based Complementary and Alternative Medicine
Volume 2011 (2011), Article ID 435928, 9 pages
http://dx.doi.org/10.1093/ecam/neq073
Original Article

Assessing the Effects of Acupuncture by Comparing Needling the Hegu Acupoint and Needling Nearby Nonacupoints by Spectral Analysis of Microcirculatory Laser Doppler Signals

1Graduate Institute of Biomedical Engineering, National Taiwan University of Science and Technology, Taipei 10607, Taiwan
2Department of Chinese Medicine, Taipei City Hospital RenAi Branch, Taipei, Taiwan
3Department of Electrical Engineering, Yuan Ze University, Taoyuan, Taiwan

Received 12 August 2009; Accepted 25 May 2010

Copyright © 2011 Hsin Hsiu et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. G. Jansen, T. Lundeberg, J. Kjartansson, and U. E. Samuelson, “Acupuncture and sensory neuropeptides increase cutaneous blood flow in rats,” Neuroscience Letters, vol. 97, no. 3, pp. 305–309, 1989. View at Google Scholar
  2. S. Uchida and H. Hotta, “Acupuncture affects regional blood flow in various organs,” Evidence-Based Complementary and Alternative Medicine, vol. 5, no. 2, pp. 145–151, 2008. View at Publisher · View at Google Scholar · View at PubMed
  3. C.-L. Hsieh, Y.-M. Chang, N.-Y. Tang et al., “Time course of changes in nail fold microcirculation induced by acupuncture stimulation at the Waiguan acupoints,” American Journal of Chinese Medicine, vol. 34, no. 5, pp. 777–785, 2006. View at Publisher · View at Google Scholar
  4. M. Inoue, H. Kitakoji, T. Yano, N. Ishizaki, M. Itoi, and Y. Katsumi, “Acupuncture treatment for low back pain and lower limb symptoms—the relation between acupuncture or electroacupuncture stimulation and sciatic nerve blood flow,” Evidence-Based Complementary and Alternative Medicine, vol. 5, no. 2, pp. 133–143, 2008. View at Publisher · View at Google Scholar · View at PubMed
  5. T.-C. Kuo, C.-W. Lin, and F.-M. Ho, “The soreness and numbness effect of acupuncture on skin blood flow,” American Journal of Chinese Medicine, vol. 32, no. 1, pp. 117–129, 2004. View at Publisher · View at Google Scholar
  6. G. Litscher, “Ten years evidence-based high-tech acupuncturea short review of peripherally measured effects,” Evidence-Based Complementary and Alternative Medicine, vol. 6, no. 2, pp. 153–158, 2009. View at Publisher · View at Google Scholar · View at PubMed
  7. R. Taguchi, “Acupuncture anesthesia and analgesia for clinical acute pain in Japan,” Evidence-Based Complementary and Alternative Medicine, vol. 5, no. 2, pp. 153–158, 2008. View at Publisher · View at Google Scholar · View at PubMed
  8. Z. Dong, L. Shun-Yue, W. Shu-You, and M. Hui-Min, “Evaluation of influence of acupuncture and electro-acupuncture for blood perfusion of stomach by laser doppler blood perfusion imaging,” Evidence-Based Complementary and Alternative Medicine. In press. View at Publisher · View at Google Scholar · View at PubMed
  9. H. Tsuru and K. Kawakita, “Acupuncture on the blood flow of various organs measured simultaneously by colored microspheres in rats,” Evidence-Based Complementary and Alternative Medicine, vol. 6, no. 1, pp. 77–83, 2009. View at Publisher · View at Google Scholar · View at PubMed
  10. F. Beissner and C. Henke, “Methodological problems in fMRI studies on acupuncture: a critical review with special emphasis on visual and auditory cortex activations,” Evidence-Based Complementary and Alternative Medicine. In press. View at Publisher · View at Google Scholar · View at PubMed
  11. G. Litscher, L. Wang, E. Huber, and G. Nilsson, “Changed skin blood perfusion in the fingertip following acupuncture needle introduction as evaluated by laser Doppler perfusion imaging,” Lasers in Medical Science, vol. 17, no. 1, pp. 19–25, 2002. View at Publisher · View at Google Scholar
  12. L. Bernardi, M. Rossi, P. Fratino, G. Finardi, E. Mevio, and C. Orlandi, “Relationship between phasic changes in human skin blood flow and autonomic tone,” Microvascular Research, vol. 37, no. 1, pp. 16–27, 1989. View at Google Scholar
  13. P. Kvandal, S. A. Landsverk, A. Bernjak, A. Stefanovska, H. D. Kvernmo, and K. A. Kirkebøen, “Low-frequency oscillations of the laser Doppler perfusion signal in human skin,” Microvascular Research, vol. 72, no. 3, pp. 120–127, 2006. View at Publisher · View at Google Scholar · View at PubMed
  14. H. Hsiu, W.-C. Hsu, S.-L. Chang, C.-L. Hsu, S.-M. Huang, and Y.-Y. Lin Wang, “Microcirculatory effect of different skin contacting pressures around the blood pressure,” Physiological Measurement, vol. 29, no. 12, pp. 1421–1434, 2008. View at Publisher · View at Google Scholar · View at PubMed
  15. H. Hsiu, W.-C. Hsu, S.-M. Huang, C.-L. Hsu, and Y.-Y. Lin Wang, “Spectral analysis of the microcirculatory laser Doppler signal at the Hoku acupuncture point,” Lasers in Medical Science, vol. 24, no. 3, pp. 353–358, 2009. View at Publisher · View at Google Scholar · View at PubMed
  16. H. Hsiu, S.-M. Huang, P.-T. Chao et al., “Microcirculatory characteristics of acupuncture points obtained by laser Doppler flowmetry,” Physiological Measurement, vol. 28, no. 10, pp. N77–N86, 2007. View at Publisher · View at Google Scholar · View at PubMed
  17. H. Hsiu, C.-L. Hsu, W.-R. Chiang et al., “Connection between RR-interval length and the pulsatile microcirculatory flow,” Physiological Measurement, vol. 29, no. 2, pp. 245–254, 2008. View at Publisher · View at Google Scholar · View at PubMed
  18. C. Freccero, F. Holmlund, S. Bornmyr et al., “Laser Doppler perfusion monitoring of skin blood flow at different depths in finger and arm upon local heating,” Microvascular Research, vol. 66, no. 3, pp. 183–189, 2003. View at Publisher · View at Google Scholar
  19. K. Lossius, M. Eriksen, and L. Walloe, “Fluctuations in blood flow to acral skin in humans: connection with heart rate and blood pressure variability,” Journal of Physiology, vol. 460, pp. 641–655, 1993. View at Google Scholar
  20. P. T. Chao, M. Y. Jan, H. Hsiu, T. L. Hsu, W. K. Wang, and Y. Y. Lin Wang, “Evaluating microcirculation by pulsatile laser Doppler signal,” Physics in Medicine and Biology, vol. 51, no. 4, pp. 845–854, 2006. View at Publisher · View at Google Scholar · View at PubMed
  21. H. D. Kvernmo, A. Stefanovska, K. A. Kirkebøen, and K. Kvernebo, “Oscillations in the human cutaneous blood perfusion signal modified by endothelium-dependent and endothelium-independent vasodilators,” Microvascular Research, vol. 57, no. 3, pp. 298–309, 1999. View at Publisher · View at Google Scholar · View at PubMed
  22. B. Suter and A. Kistler, “Does acupuncture influence the cardiovascular system via the central nervous system?” Schweizerische Medizinische Wochenschrift, vol. 124, no. 62, pp. 36–38, 1994. View at Google Scholar
  23. T. Söderström, A. Stefanovska, M. Veber, and H. Svensson, “Involvement of sympathetic nerve activity in skin blood flow oscillations in humans,” American Journal of Physiology—Heart and Circulatory Physiology, vol. 284, no. 5, pp. H1638–H1646, 2003. View at Google Scholar
  24. H. M. Stauss, E. A. Anderson, W. G. Haynes, and K. C. Kregel, “Frequency response characteristics of sympathetically mediated vasomotor waves in humans,” American Journal of Physiology—Heart and Circulatory Physiology, vol. 274, no. 4, part 2, pp. H1277–H1283, 1998. View at Google Scholar
  25. M. Ernst and M. H. M. Lee, “Sympathetic effects of manual and electrical acupuncture of the Tsusanli knee point: comparison with the Hoku hand point sympathetic effects,” Experimental Neurology, vol. 94, no. 1, pp. 1–10, 1986. View at Google Scholar
  26. H. R. Middlekauff, “Acupuncture in the treatment of heart failure,” Cardiology in Review, vol. 12, no. 3, pp. 171–173, 2004. View at Publisher · View at Google Scholar
  27. Y. Sugiyama, Y. X. Xue, and T. Mano, “Transient increase in human muscle sympathetic nerve activity during manual acupuncture,” Japanese Journal of Physiology, vol. 45, no. 2, pp. 337–345, 1995. View at Google Scholar
  28. D. Thomas, S. Collins, and S. Strauss, “Somatic sympathetic vasomotor changes documented by medical thermographic imaging during acupuncture analgesia,” Clinical Rheumatology, vol. 11, no. 1, pp. 55–59, 1992. View at Google Scholar
  29. S. Knardahl, M. Elam, B. Olausson, and B. G. Wallin, “Sympathetic nerve activity after acupuncture in humans,” Pain, vol. 75, no. 1, pp. 19–25, 1998. View at Publisher · View at Google Scholar
  30. X. D. Cao, S. F. Xu, and W. X. Lu, “Inhibition of sympathetic nervous system by acupuncture,” Acupuncture and Electro-Therapeutics Research, vol. 8, no. 1, pp. 25–35, 1983. View at Google Scholar
  31. H. Ohsawa, K. Okada, K. Nishijo, and Y. Sato, “Neural mechanism of depressor responses of arterial pressure elicited by acupuncture-like stimulation to a hindlimb in anesthetized rats,” Journal of the Autonomic Nervous System, vol. 51, no. 1, pp. 27–35, 1995. View at Publisher · View at Google Scholar
  32. Y. C. Hwang, “Anatomy and classification of acupoints,” Problems in Veterinary Medicine, vol. 4, no. 1, pp. 12–15, 1992. View at Google Scholar
  33. K. Nishijo, H. Mori, K. Yosikawa, and K. Yazawa, “Decreased heart rate by acupuncture stimulation in humans via facilitation of cardiac vagal activity and suppression of cardiac sympathetic nerve,” Neuroscience Letters, vol. 227, no. 3, pp. 165–168, 1997. View at Publisher · View at Google Scholar
  34. Y.-Y. Lin Wang, M.-Y. Jan, C.-S. Shyu, C.-A. Chiang, and W.-K. Wang, “The natural frequencies of the arterial system and their relation to the heart rate,” IEEE Transactions on Biomedical Engineering, vol. 51, no. 1, pp. 193–195, 2004. View at Publisher · View at Google Scholar · View at PubMed
  35. H. Hsiu, P.-T. Chao, W.-C. Hsu, M.-Y. Jan, Y.-Y. Lin Wang, and W.-K. Wang, “The possible role of arterial radial vibration in heart rate and blood pressure matching,” Proceedings of the Institution of Mechanical Engineers H, vol. 222, no. 5, pp. 773–779, 2008. View at Publisher · View at Google Scholar
  36. C. H. Baker and E. T. Sutton, “Antagonism of acetylcholine and adenosine rat cremaster arteriolar vasodilation by combination of NO antagonists,” International Journal of Microcirculation, Clinical and Experimental, vol. 12, no. 3, pp. 275–286, 1993. View at Google Scholar
  37. N.-T. Jou and S.-X. Ma, “Responses of nitric oxide—cGMP release in acupuncture point to electroacupuncture in human skin in vivo using dermal microdialysis,” Microcirculation, vol. 16, no. 5, pp. 434–443, 2009. View at Publisher · View at Google Scholar · View at PubMed
  38. J. Hao, C. Zhao, S. Cao, and S. Yang, “Electric acupuncture treatment of peripheral nerve injury,” Journal of Traditional Chinese Medicine, vol. 15, no. 2, pp. 114–117, 1995. View at Google Scholar
  39. M. F. O'Rourke and W. W. Nichols, “Aortic diameter, aortic stiffness, and wave reflection increase with age and isolated systolic hypertension,” Hypertension, vol. 45, no. 4, pp. 652–658, 2005. View at Publisher · View at Google Scholar · View at PubMed
  40. W. K. Wang, T. L. Hsu, and Y. Y. L. Wang, “Liu-Wei-Dihuang: a study by pulse analysis,” American Journal of Chinese Medicine, vol. 26, no. 1, pp. 73–82, 1998. View at Google Scholar
  41. W. K. Wang, T. Lin Hsu, H. C. Chang, and Y. Y. Lin Wang, “Effect of acupuncture at Hsien-Ku (St-43) on the pulse spectrum and a discussion of the evidence for the frequency structure of Chinese medicine,” American Journal of Chinese Medicine, vol. 28, no. 1, pp. 41–55, 2000. View at Google Scholar