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Evidence-Based Complementary and Alternative Medicine
Volume 2011, Article ID 438056, 17 pages
http://dx.doi.org/10.1155/2011/438056
Review Article

Practices in Wound Healing Studies of Plants

1Biochemical Research Laboratory, Centre for Scientific Research and Development, People's Group, Bhopal, Madhya Pradesh 462037, India
2Department of Biotechnology, Maharishi Markandeshwar University, Mullana, Ambala, Haryana 133207, India

Received 5 August 2010; Revised 21 January 2011; Accepted 24 February 2011

Copyright © 2011 Rupesh Thakur et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Wounds are the result of injuries to the skin that disrupt the other soft tissue. Healing of a wound is a complex and protracted process of tissue repair and remodeling in response to injury. Various plant products have been used in treatment of wounds over the years. Wound healing herbal extracts promote blood clotting, fight infection, and accelerate the healing of wounds. Phytoconstituents derived from plants need to be identified and screened for antimicrobial activity for management of wounds. The in vitro assays are useful, quick, and relatively inexpensive. Small animals provide a multitude of model choices for various human wound conditions. The study must be conducted after obtaining approval of the Ethics Committee and according to the guidelines for care and use of animals. The prepared formulations of herbal extract can be evaluated by various physicopharmaceutical parameters. The wound healing efficacies of various herbal extracts have been evaluated in excision, incision, dead space, and burn wound models. In vitro and in vivo assays are stepping stones to well-controlled clinical trials of herbal extracts.