Biphasic Effect of Curcumin on Morphine Tolerance: A Preliminary Evidence from Cytokine/Chemokine Protein Array Analysis

Figure 5

Cumulative dose-response curve on Day 8. Formulas of drug injections, including Mo-NS, Mo-DMSO, Mo-25 Cur andMo-400 Cur, indicate morphine (10 mg kg^-1, s.c.) followed by normal saline (100 𝜇L, i.p.), morphine (10 mg kg^-1, s.c.) followed by DMSO (100 𝜇L, i.p.), morphine (10 mg kg^-1, s.c.) followed by low-dose curcumin (25 mg kg^-1, i.p.) and high-dose curcumin (400 mg kg^-1, i.p.), respectively, for 7 days. The interval between injections in each group was 15 min.