A Chinese Herbal Decoction, Modified Yi Guan Jian, Induces Apoptosis in Hepatic Stellate Cells through an ROS-Mediated Mitochondrial/Caspase Pathway

<table>Hypothetical pathways by which mYGJ induces apoptosis of HSC-T6 cells. mYGJ promotes proapoptotic factor Bax expression, decreases antiapoptotic factor Bcl-2 expression, and along with the accumulation of ROS facilitates calcium and cytochrome c release to cytosol followed by activation of caspase 9 and caspase 3 leading to apoptosis. On the other hand, mYGJ may induce ER stress that results in an increase in cytosolic calcium concentration and activates-ER-associated caspase 12 subsequently joints the activation of caspase 9/ 3 cascade.</table>

Evidence-Based Complementary and Alternative Medicine

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Figure 4: A Chinese Herbal Decoction, Modified Yi Guan Jian, Induces Apoptosis in Hepatic Stellate Cells through an ROS-Mediated Mitochondrial/Caspase Pathway 

Figure 4 | A Chinese Herbal Decoction, Modified Yi Guan Jian, Induces Apoptosis in Hepatic Stellate Cells through an ROS-Mediated Mitochondrial/Caspase Pathway 