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Evidence-Based Complementary and Alternative Medicine
Volume 2011, Article ID 484590, 10 pages
http://dx.doi.org/10.1093/ecam/nep052
Original Article

Preventive Effects of Salacia reticulata on Obesity and Metabolic Disorders in TSOD Mice

1Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan
2Research Institute of Pharmaceutical Sciences, Musashino University, 1-1-20 Shinmachi Nishitokyo-shi, Tokyo 202-8585, Japan
3Graduate School of Natural Science and Technology, Kanazawa University, Kakuma-machi Kanazawa-shi, Ishikawa 920-1192, Japan
4Department of Pharmacy, Saiseikai Yokohama Tobu-Hospital, 3-6-1 Simosueyoshi Turumi-ku Yokohama-city, Kanagawa 230-0012, Japan
5Department of Pharmacy, Ritsumeikan University, 1-1-1 Noji-higashi, Kusatsu, Shiga 525-8577, Japan
6Graduate School of Medicine, Hokkaido University, North-15, West-7, Kita-ku, Hokkaido, 060-8638, Japan

Received 22 December 2008; Accepted 23 April 2009

Copyright © 2011 Tomoko Akase et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

The extracts of Salacia reticulata (Salacia extract), a plant that has been used for the treatment of early diabetes, rheumatism and gonorrhea in Ayurveda, have been shown to have an anti-obesity effect and suppress hyperglycemia. In this study, the effects of Salacia extract on various symptoms of metabolic disorder were investigated and compared using these TSOD mice and non-obese TSNO mice. Body weight, food intake, plasma biochemistry, visceral and subcutaneous fat (X-ray and CT), glucose tolerance, blood pressure and pain tolerance were measured, and histopathological examination of the liver was carried out. A significant dose-dependent decline in the gain in body weight, accumulation of visceral and subcutaneous fat and an improvement of abnormal glucose tolerance, hypertension and peripheral neuropathy were noticed in TSOD mice. In addition, hepatocellular swelling, fatty degeneration of hepatocytes, inflammatory cell infiltration and single-cell necrosis were observed on histopathological examination of the liver in TSOD mice. Salacia extract markedly improved these symptoms upon treatment. Based on the above results, it is concluded that Salacia extract has remarkable potential to prevent obesity and associated metabolic disorders including the development of metabolic syndrome.