An Antioxidant Phytotherapy to Rescue Neuronal Oxidative Stress

Table 2

Effects of the aqueous extract of FBD on the contents of MDA, NO and GSH, and SOD activity in rat brain subject to MCAO.

Group	Dose (mg/kg)	NO (μmol/g prot)	MDA (μmol/g prot)	GSH (μmol/g prot)	SOD (U/mg prot)
Sham		4.58 ± 0.75	3.77 ± 0.83	45.33 ± 5.54	143.07 ± 26.65
MCAO		7.94 ± 0.74^##	6.68 ± 0.54^##	27.08 ± 3.92^##	96.57 ± 22.78^##
EGb761	24	6.01 ± 0.96**	4.56 ± 1.72**	35.03 ± 6.06**	124.43 ± 15.77**
FBD	250	6.25 ± 0.80**	4.64 ± 0.96**	32.51 ± 5.00*	131.73 ± 22.40**

All the data were shown as the mean ± SD, n = 10−12. Significance was evaluated with one-way analysis of variance (ANOVA) following by two-sided Dunnett's 𝑡-test. ^##𝑃<.01 versus the sham-operated group; ^∗𝑃<.05, ^∗∗𝑃<.01 versus the vehicle-pretreated MCAO group.