YesNo significant group difference for demographics, baseline knee pain, radiographic status or compliance
Yes
No, but clear from methodology this was a double blind study
Yes
Yes
Yes
18% (/80)
18% (/84)
per group plus 10 for drop outs, to detect a difference of 3, 4, or 5 units in WOMAC pain 80% power and = 0.05 ITT analysis. Primary outcomes: analysis of covariance
Yes
LOCF Except for missing baseline data which were replaced with day 1 scores
Yes No significant group differences at baseline for sex, age, height, wgt, and symptom duration, NSAID use, MSM or DMSO use, ACR classification, baseline VAS scores, PGA or PhGA scores, and radiological stage
Yes
Yes
Yes
Yes
Yes
16% /25)
24% /25)
Yes ITT analysis Group differences in baseline to week 12 by T test