Evidence-Based Complementary and Alternative Medicine / 2011 / Article / Tab 5

Original Article

Meta-Analysis of the Related Nutritional Supplements Dimethyl Sulfoxide and Methylsulfonylmethane in the Treatment of Osteoarthritis of the Knee

Table 5

Meta-analysis results.

StudyYearDesignAnalyzed patients (intervention/ placebo)InterventionDaily DoseBaseline pain score (mm)End of Rx pain score (mm)Pain outcome measureMean SE reduction from baseline with active treatment (mm) (95% CI)Mean SE reduction from baseline with placebo (mm) (95% CI)Mean Difference SE in pain scores between groups (mm) (95% CI) Effect Size

Eberhardt et al. [56]1995Single centre Double blind placebo controlled parallelDMSO: 56 Placebo: 56DMSO25% DMSO gel/day 5–8 cmDMSO = 64.3 Placebo = 64.1DMSO = 21.6 Placebo = 33.3Pain VAS (0–100 mm)42.7 2.34 [ ]30.8 2.38 [ ]11.7 3.31 [ ] Effect = 3.53
Bookman et al. [36]2004Multi centre, Double blind, three arma comparative parallel armDMSO: 79 Placebo: 84DMSO45.5% wt/wtDMSO = 46.5 Placebo = 47.0DMSO = 34.0 Placebo = 34.5WOMAC pain subscale (0–20 m ) (scaled up to 100 mm for comparison)12.5 2.7 [ ]12.5 2.0 [ ]0.0 3.35 [ ] Effect = 0.00
Kim et al. [43]2006Single centre, double blind placebo controlled parallel armMSM: 21 Placebo: 19MSM3 g/day oralMSM = 58.0 Placebo = 55.1MSM = 43.4 Placebo = 47.9WOMAC pain subscale (0–100 mm)14.6 1.3 [ ]7.3 3.3 [ ]7.3 3.55 [ ] Effect = 2.06
6.34 1.96 [2.41, 10.27]
Meta-analyses (fixed effects)6.34 3.49 [ ]
Meta-analysis (random effects)

aThis three-armed study assessed Diclofenac, DMSO and placebo; only data for DMSO and placebo is entered. bSee our review paper.

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