Oral Treatment with Extract of Agaricus blazei Murill Enhanced Th1 Response through Intestinal Epithelial Cells and Suppressed OVA-Sensitized Allergy in Mice

Figure 5

Effect of ABME on the cytokine profile of anti-CD3𝜀/CD28 antibody-stimulated splenocytes in OVA-sensitized mice. Spleen cells from the mice of each group were stimulated with 5 𝜇g/ml each of anti-CD3𝜀/28 antibody at 37^∘C for 48 h. After incubation, the IL-4 (a), IL-5 (b), IL-10 (c), and IFN-𝛾 (d) in the culture medium were determined using a cytometric bead array immunoassay. Values represent the means ± S.E. of 5 mice in each group. ^∗𝑃<.05,　 ^∗∗𝑃<.01, significantly different from the values of the control group.

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