Oral Treatment with Extract of Agaricus blazei Murill Enhanced Th1 Response through Intestinal Epithelial Cells and Suppressed OVA-Sensitized Allergy in Mice
Figure 9
Shift in Th1/Th2 balance to Th1 by ABME through intestinal epithelial cells. An intestinal epithelial cell is stimulated by FIII-2-b in ABME, which binds to a certain receptor. This stimulus produces second messengers, likely H2O2. Macrophages result in enhancement of TNF- and IFN- production. Produced INF- affects Th1/Th2 balance which is important for allergy, and promotes the negative regulation of IL-4, 5, 10 which induce Th2 cell dominance, resulting in Th1 cell dominance in immune system.
